| Title: | International Union of Basic and Clinical Pharmacology. LXXVI. Current progress in the mammalian TRP ion channel family |
| Author(s): | Wu LJ; Sweet TB; Clapham DE; |
| Address: | "Howard Hughes Medical Institute, Department of Cardiology, Children's Hospital Boston, 320 Longwood Avenue, Boston, MA 02115, USA" |
| ISSN/ISBN: | 1521-0081 (Electronic) 0031-6997 (Print) 0031-6997 (Linking) |
| Abstract: | "Transient receptor potential (TRP) channels are a large family of ion channel proteins, surpassed in number in mammals only by voltage-gated potassium channels. TRP channels are activated and regulated through strikingly diverse mechanisms, making them suitable candidates for cellular sensors. They respond to environmental stimuli such as temperature, pH, osmolarity, pheromones, taste, and plant compounds, and intracellular stimuli such as Ca(2+) and phosphatidylinositol signal transduction pathways. However, it is still largely unknown how TRP channels are activated in vivo. Despite the uncertainties, emerging evidence using TRP channel knockout mice indicates that these channels have broad function in physiology. Here we review the recent progress on the physiology, pharmacology and pathophysiological function of mammalian TRP channels" |
| Keywords: | Animals Humans Ion Channel Gating Mammals Transient Receptor Potential Channels/*classification/*physiology; |
| Notes: | "MedlineWu, Long-Jun Sweet, Tara-Beth Clapham, David E eng R01 MH090293/MH/NIMH NIH HHS/ T32 HL007572/HL/NHLBI NIH HHS/ R01-MH090293-01/MH/NIMH NIH HHS/ HHMI/Howard Hughes Medical Institute/ Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review 2010/08/19 Pharmacol Rev. 2010 Sep; 62(3):381-404. doi: 10.1124/pr.110.002725" |
