| Title: | Indoor volatile organic compounds and chemical sensitivity reactions |
| Author(s): | Win-Shwe TT; Fujimaki H; Arashidani K; Kunugita N; |
| Address: | "Center for Environmental Health Sciences, National Institute for Environmental Studies, Tsukuba, Ibaraki 305-8506, Japan" |
| ISSN/ISBN: | 1740-2530 (Electronic) 1740-2522 (Print) 1740-2522 (Linking) |
| Abstract: | "Studies of unexplained symptoms observed in chemically sensitive subjects have increased the awareness of the relationship between neurological and immunological diseases due to exposure to volatile organic compounds (VOCs). However, there is no direct evidence that links exposure to low doses of VOCs and neurological and immunological dysfunction. We review animal model data to clarify the role of VOCs in neuroimmune interactions and discuss our recent studies that show a relationship between chronic exposure of C3H mice to low levels of formaldehyde and the induction of neural and immune dysfunction. We also consider the possible mechanisms by which VOC exposure can induce the symptoms presenting in patients with a multiple chemical sensitivity" |
| Keywords: | "Air Pollution, Indoor/*adverse effects Animals Brain/drug effects/metabolism Environmental Illness/*chemically induced Formaldehyde/adverse effects Gene Expression Hypothalamo-Hypophyseal System/drug effects Mice Neuroimmunomodulation/drug effects Neurotr;" |
| Notes: | "MedlineWin-Shwe, Tin-Tin Fujimaki, Hidekazu Arashidani, Keiichi Kunugita, Naoki eng Research Support, Non-U.S. Gov't Review Egypt 2013/11/15 Clin Dev Immunol. 2013; 2013:623812. doi: 10.1155/2013/623812. Epub 2013 Oct 21" |
