| Title: | A detoxification pathway initiated by a nuclear receptor TcHR96h in Tetranychus cinnabarinus (Boisduval) |
| Author(s): | Wen X; Feng K; Qin J; Wei P; Cao P; Zhang Y; Yuchi Z; He L; |
| Address: | "Key Laboratory of Entomology and Pest Control Engineering, College of Plant Protection, Southwest University, Chongqing, China. Key Laboratory of Agricultural Biosafety and Green Production of Upper Yangtze River, Ministry of Education, Chongqing, China. National Citrus Engineering Research Center, Southwest University, Chongqing, China. Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, Collaborative Innovation Center of Chemical Science and Engineering, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin, China. Key Laboratory of Drug Targets and Drug Leads for Degenerative Diseases, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, China. Department of Plants and Crops, Institute of Vegetables and Flowers, Chinese Academy of Agricultural Sciences, Beijing, China" |
| DOI: | 10.1371/journal.pgen.1010911 |
| ISSN/ISBN: | 1553-7404 (Electronic) 1553-7390 (Print) 1553-7390 (Linking) |
| Abstract: | "Understanding the mechanism of detoxification initiation in arthropods after pesticide exposure is crucial. Although the identity of transcription factors that induce and regulate the expression of detoxification genes in response to pesticides is beginning to emerge, whether transcription factors directly interact with xenobiotics is unclear. The findings of this study revealed that a nuclear hormone receptor, Tetranychus cinnabarinus hormone receptor (HR) TcHR96h, regulates the overexpression of the detoxification gene TcGSTm02, which is involved in cyflumetofen resistance. The nuclear translocation of TcHR96h increased after cyflumetofen exposure, suggesting direct binding with cyflumetofen. The direct binding of TcHR96h and cyflumetofen was supported by several independent proteomic assays that quantify interactions with small molecules. Together, this study proposes a model for the initiation of xenobiotic detoxification in a polyphagous agricultural pest. These insights not only provide a better understanding of the mechanisms of xenobiotic detoxification and metabolism in arthropods, but also are crucial in understanding adaptation in polyphagous herbivores" |
| Keywords: | "Animals Proteomics Xenobiotics Receptors, Cytoplasmic and Nuclear/genetics Transcription Factors *Arthropods *Tetranychidae/genetics;" |
| Notes: | "MedlineWen, Xiang Feng, Kaiyang Qin, Juan Wei, Peng Cao, Peng Zhang, Youjun Yuchi, Zhiguang He, Lin eng Research Support, Non-U.S. Gov't 2023/09/14 PLoS Genet. 2023 Sep 14; 19(9):e1010911. doi: 10.1371/journal.pgen.1010911. eCollection 2023 Sep" |
