« Previous AbstractBoll weevil (Coleoptera: Curculionidae) bait sticks: toxicity and malathion content    Next AbstractAnalysis of odour and taste problems in high-density polyethene »

Nutr J

Title:		High dietary total antioxidant capacity is associated with a reduced risk of hypertension in French women
Author(s):		Villaverde P; Lajous M; MacDonald CJ; Fagherazzi G; Bonnet F; Boutron-Ruault MC;
Address:		"Center for Research on Population Health, INSP (Instituto Nacional de Salud Publica), Cuernavaca, Mexico. INSERM (Institut National de la Sante et de la Recherche Medicale) U1018, Center for Research in Epidemiology and Population Health (CESP), Institut Gustave Roussy, Villejuif, France. Universite Paris-Saclay, Universite Paris-Sud, Villejuif, France. Department of Global Health and Population, Harvard T.H. Chan School of Public Health, Boston, MA, USA. Universite Rennes1, F-35043, Rennes, France. CHU Rennes, F-35033, Rennes, France. INSERM (Institut National de la Sante et de la Recherche Medicale) U1018, Center for Research in Epidemiology and Population Health (CESP), Institut Gustave Roussy, Villejuif, France. marie-christine.boutron@gustaveroussy.fr. Universite Paris-Saclay, Universite Paris-Sud, Villejuif, France. marie-christine.boutron@gustaveroussy.fr"
Journal Title:		Nutr J
Year:		2019
Volume:		20190611
Issue:		1
Page Number:		31 -
DOI:		10.1186/s12937-019-0456-0
ISSN/ISBN:		1475-2891 (Electronic) 1475-2891 (Linking)
Abstract:		"BACKGROUND: Although there is evidence for a reduced risk of hypertension associated with fruit and vegetable consumption, the relationship between the total antioxidant capacity of the diet (TAC) and the risk of hypertension has not been previously examined. We aimed to evaluate that association in the large E3N French prospective cohort of women. METHODS: Dietary TAC was estimated using total radical-trapping ability parameter (TRAP) assay food values; self-reported incident hypertension cases were validated. Cox regression models were adjusted for conventional risk factors, body mass index, physical activity, energy, sodium, magnesium, omega-3 fatty acids, and alcohol. RESULTS: After an average 12.7 years of follow up, there were 9350 incident cases of hypertension among 40,576 women. Dietary TAC was inversely associated with the risk of hypertension with a 15% lower risk of hypertension in those in the fifth vs. first quintile (HR(Q5) 0.85 [CI 95% 0.74; 0.95] p-trend 0.03) An inverse dose-effect relationship was observed for dietary TAC excluding coffee (HR(Q5) 0.85 [CI 95% 0.74; 0.95], p-trend 0.0008), while for dietary TAC from coffee, only the highest quintile was inversely associated with risk (HR(Q5) 0.86 [0.75, 0.97], p-trend 0.20). In a fully partitioned model with major dietary TAC contributors, TAC from fruit/vegetables, wine, and miscellaneous sources was inversely associated with risk, while associations with TAC from coffee, tea, and chocolate were not statistically significant. CONCLUSIONS: In a large prospective cohort, the risk of incident hypertension in women was inversely associated with the antioxidant capacity of the diet, suggesting that promoting a diet naturally rich in antioxidants might help prevent the development of hypertension"
Keywords:		Adult Aged Antioxidants/*administration & dosage Cohort Studies Diet/*methods Female France/epidemiology Humans Hypertension/*epidemiology Middle Aged Prospective Studies Risk Assessment Dietary total antioxidant capacity Hypertension TRAP assay Women;
Notes:		"MedlineVillaverde, Paola Lajous, Martin MacDonald, Conor-James Fagherazzi, Guy Bonnet, Fabrice Boutron-Ruault, Marie-Christine eng Research Support, Non-U.S. Gov't England 2019/06/13 Nutr J. 2019 Jun 11; 18(1):31. doi: 10.1186/s12937-019-0456-0"