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Brain Struct Funct

Title:		The integrity of the nucleus of the lateral olfactory tract is essential for the normal functioning of the olfactory system
Author(s):		Vaz RP; Cardoso A; Sa SI; Pereira PA; Madeira MD;
Address:		"Unit of Anatomy, Department of Biomedicine, Faculty of Medicine, University of Porto, Alameda Professor Hernani Monteiro, 4200-319, Porto, Portugal. rvaz@med.up.pt. Otorhinolaryngology Department, Centro Hospitalar S. Joao, EPE, Alameda Professor Hernani Monteiro, 4200-319, Porto, Portugal. rvaz@med.up.pt. Center for Health Technology and Services Research (CINTESIS), Rua Dr. Placido da Costa, 4200-450, Porto, Portugal. rvaz@med.up.pt. Unit of Anatomy, Department of Biomedicine, Faculty of Medicine, University of Porto, Alameda Professor Hernani Monteiro, 4200-319, Porto, Portugal. Center for Health Technology and Services Research (CINTESIS), Rua Dr. Placido da Costa, 4200-450, Porto, Portugal"
Journal Title:		Brain Struct Funct
Year:		2017
Volume:		20170419
Issue:		8
Page Number:		3615 - 3637
DOI:		10.1007/s00429-017-1422-2
ISSN/ISBN:		1863-2661 (Electronic) 1863-2653 (Print) 1863-2653 (Linking)
Abstract:		"The nucleus of the lateral olfactory tract (nLOT) is a relatively small component of the cortical pallial amygdala, with peculiar neurogenic, neurochemical and connectivity patterns. Although it has been suggested that it might be involved in non-pheromonal olfactory-guided behaviors, particularly feeding, the functional implications of the nLOT have never been investigated. In view of this fact, we have tackled this subject by performing a series of behavioral tests and by quantifying biological and biochemical parameters in sexually naive adult male rats that were submitted to bilateral excitotoxic lesions of the nLOT. nLOT-lesioned rats had severe olfactory deficits with inability to detect and discriminate between odors. Additionally, they did not display innate behavioral responses to biologically relevant chemosignals. Specifically, nLOT-lesioned rats did not show avoidance towards predator odors or aggressive behaviors towards intruders, and had severely impaired sexual behavior. In fact, nLOT lesions abolished preference for odors of receptive females, reduced chemoinvestigatory behavior and eliminated mounting behavior. nLOT-lesioned rats had normal circulating levels of testosterone, did not display anxiety- or depressive-like behaviors, and had unimpaired cognitive functions and fear acquisition and memory. Altogether, our results suggest that the nLOT integrity is required for the normal functioning of the olfactory system"
Keywords:		"Aggression Animals Anxiety Avoidance Learning *Behavior, Animal Depression Discrimination, Psychological Male Odorants Olfactory Bulb/*physiology Rats, Wistar Sexual Behavior, Animal *Smell Anosmia Attractive and avoidance behaviors Cortical pallial amygd;"
Notes:		"MedlineVaz, Ricardo P Cardoso, Armando Sa, Susana I Pereira, Pedro A Madeira, M Dulce eng Germany 2017/04/21 Brain Struct Funct. 2017 Nov; 222(8):3615-3637. doi: 10.1007/s00429-017-1422-2. Epub 2017 Apr 19"