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BMC Biol

Title:		The impact of skin care products on skin chemistry and microbiome dynamics
Author(s):		Bouslimani A; da Silva R; Kosciolek T; Janssen S; Callewaert C; Amir A; Dorrestein K; Melnik AV; Zaramela LS; Kim JN; Humphrey G; Schwartz T; Sanders K; Brennan C; Luzzatto-Knaan T; Ackermann G; McDonald D; Zengler K; Knight R; Dorrestein PC;
Address:		"Collaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, San Diego, USA. Department of Pediatrics, University of California, San Diego, La Jolla, CA, 92037, USA. Department for Pediatric Oncology, Hematology and Clinical Immunology, University Children's Hospital, Medical Faculty, Heinrich-Heine-University Dusseldorf, Dusseldorf, Germany. Center for Microbial Ecology and Technology, Ghent University, 9000, Ghent, Belgium. Center for Microbiome Innovation, University of California, San Diego, La Jolla, CA, 92307, USA. Department of Bioengineering, University of California, San Diego, La Jolla, CA, 92093, USA. Department of Pediatrics, University of California, San Diego, La Jolla, CA, 92037, USA. rknight@ucsd.edu. Center for Microbiome Innovation, University of California, San Diego, La Jolla, CA, 92307, USA. rknight@ucsd.edu. Department of Bioengineering, University of California, San Diego, La Jolla, CA, 92093, USA. rknight@ucsd.edu. Department of Computer Science and Engineering, University of California, San Diego, La Jolla, CA, 92093, USA. rknight@ucsd.edu. Collaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, San Diego, USA. pdorrestein@ucsd.edu. Department of Pediatrics, University of California, San Diego, La Jolla, CA, 92037, USA. pdorrestein@ucsd.edu. Center for Microbiome Innovation, University of California, San Diego, La Jolla, CA, 92307, USA. pdorrestein@ucsd.edu. Department of Pharmacology, University of California, San Diego, La Jolla, CA, 92037, USA. pdorrestein@ucsd.edu"
Journal Title:		BMC Biol
Year:		2019
Volume:		20190612
Issue:		1
Page Number:		47 -
DOI:		10.1186/s12915-019-0660-6
ISSN/ISBN:		1741-7007 (Electronic) 1741-7007 (Linking)
Abstract:		"BACKGROUND: Use of skin personal care products on a regular basis is nearly ubiquitous, but their effects on molecular and microbial diversity of the skin are unknown. We evaluated the impact of four beauty products (a facial lotion, a moisturizer, a foot powder, and a deodorant) on 11 volunteers over 9 weeks. RESULTS: Mass spectrometry and 16S rRNA inventories of the skin revealed decreases in chemical as well as in bacterial and archaeal diversity on halting deodorant use. Specific compounds from beauty products used before the study remain detectable with half-lives of 0.5-1.9 weeks. The deodorant and foot powder increased molecular, bacterial, and archaeal diversity, while arm and face lotions had little effect on bacterial and archaeal but increased chemical diversity. Personal care product effects last for weeks and produce highly individualized responses, including alterations in steroid and pheromone levels and in bacterial and archaeal ecosystem structure and dynamics. CONCLUSIONS: These findings may lead to next-generation precision beauty products and therapies for skin disorders"
Keywords:		Adult Cosmetics/*adverse effects/classification Female Humans Male Microbiota/*drug effects Skin/chemistry/*drug effects/microbiology Skin Care/*adverse effects 16S rRNA sequencing Bacteria Mass spectrometry Metabolomics Skin Skin care products;
Notes:		"MedlineBouslimani, Amina da Silva, Ricardo Kosciolek, Tomasz Janssen, Stefan Callewaert, Chris Amir, Amnon Dorrestein, Kathleen Melnik, Alexey V Zaramela, Livia S Kim, Ji-Nu Humphrey, Gregory Schwartz, Tara Sanders, Karenina Brennan, Caitriona Luzzatto-Knaan, Tal Ackermann, Gail McDonald, Daniel Zengler, Karsten Knight, Rob Dorrestein, Pieter C eng Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. England 2019/06/14 BMC Biol. 2019 Jun 12; 17(1):47. doi: 10.1186/s12915-019-0660-6"