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Cell

Title:		LUSH shapes up for a starring role in olfaction
Author(s):		Stowers L; Logan DW;
Address:		"Department of Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA. stowers@scripps.edu"
Journal Title:		Cell
Year:		2008
Volume:		133
Issue:		7
Page Number:		1137 - 1139
DOI:		10.1016/j.cell.2008.06.010
ISSN/ISBN:		1097-4172 (Electronic) 0092-8674 (Linking)
Abstract:		"In the fruit fly Drosophila, odorant-binding proteins are secreted into the fluid that bathes olfactory neurons. Laughlin et al. (2008) now challenge the assumption that the odorant-binding protein LUSH passively transports its pheromone to a specific olfactory receptor. Instead, LUSH undergoes a conformational change upon pheromone binding that is sufficient for neuronal activation"
Keywords:		"Animals Drosophila melanogaster/*metabolism Olfactory Receptor Neurons/*metabolism Pheromones/metabolism Protein Conformation Receptors, Odorant/*chemistry/*metabolism *Smell;"
Notes:		"MedlineStowers, Lisa Logan, Darren W eng Comment 2008/07/01 Cell. 2008 Jun 27; 133(7):1137-9. doi: 10.1016/j.cell.2008.06.010"