| Title: | Exhaled volatile organic compounds analysis in clinical pediatrics: a systematic review |
| Author(s): | Sola Martinez RA; Pastor Hernandez JM; Yanes Torrado O; Canovas Diaz M; de Diego Puente T; Vinaixa Crevillent M; |
| Address: | "Department of Biochemistry and Molecular Biology (B) and Immunology, University of Murcia and Murcian Institute of Biosanitary Research Virgen de la Arrixaca (IMIB), Murcia, Spain. Department of Electronic Engineering, Universitat Rovira i Virgili, Tarragona, Spain. Institut d'Investigacio Sanitaria Pere Virgili (IISPV), Metabolomics Platform, Reus, Spain. CIBER de Diabetes y Enfermedades Metabolicas Asociadas (CIBERDEM), Instituto de Salud Carlos III, Madrid, Spain. Department of Biochemistry and Molecular Biology (B) and Immunology, University of Murcia and Murcian Institute of Biosanitary Research Virgen de la Arrixaca (IMIB), Murcia, Spain. tdp@um.es" |
| DOI: | 10.1038/s41390-020-01116-8 |
| ISSN/ISBN: | 1530-0447 (Electronic) 0031-3998 (Linking) |
| Abstract: | "BACKGROUND: Measured exhaled volatile organic compounds (VOCs) in breath also referred to as exhaled volatilome have been long claimed as a potential source of non-invasive and clinically applicable biomarkers. However, the feasibility of using exhaled volatilome in clinical practice remains to be demonstrated, particularly in pediatrics where the need for improved non-invasive diagnostic and monitoring methods is most urgent. This work presents the first formal evidence-based judgment of the clinical potential of breath volatilome in the pediatric population. METHODS: A rigorous systematic review across Web of Science, SCOPUS, and PubMed databases following the PRISMA statement guidelines. A narrative synthesis of the evidence was conducted and QUADAS-2 was used to assess the quality of selected studies. RESULTS: Two independent reviewers deemed 22 out of the 229 records initially found to satisfy inclusion criteria. A summary of breath VOCs found to be relevant for several respiratory, infectious, and metabolic pathologies was conducted. In addition, we assessed their associated metabolism coverage through a functional characterization analysis. CONCLUSION: Our results indicate that current research remains stagnant in a preclinical exploratory setting. Designing exploratory experiments in compliance with metabolomics practice should drive forward the clinical translation of VOCs breath analysis. IMPACT: What is the key message of your article? Metabolomics practice could help to achieve the clinical utility of exhaled volatilome analysis. What does it add to the existing literature? This work is the first systematic review focused on disease status discrimination using analysis of exhaled breath in the pediatric population. A summary of the reported exhaled volatile organic compounds is conducted together with a functional characterization analysis. What is the impact? Having noted challenges preventing the clinical translation, we summary metabolomics practices and the experimental designs that are closer to clinical practice to create a framework to guide future trials" |
| Keywords: | Breath Tests/*methods Child Exhalation Humans Metabolomics *Pediatrics Volatile Organic Compounds/*analysis; |
| Notes: | "MedlineSola Martinez, Rosa A Pastor Hernandez, Jose M Yanes Torrado, Oscar Canovas Diaz, Manuel de Diego Puente, Teresa Vinaixa Crevillent, Maria eng Research Support, Non-U.S. Gov't Systematic Review 2020/09/13 Pediatr Res. 2021 May; 89(6):1352-1363. doi: 10.1038/s41390-020-01116-8. Epub 2020 Sep 12" |
