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Antimicrob Agents Chemother

Title:		High-level plasmid-mediated gentamicin resistance and pheromone response of plasmids present in clinical isolates of Enterococcus faecalis
Author(s):		Shiojima M; Tomita H; Tanimoto K; Fujimoto S; Ike Y;
Address:		"Department of Microbiology, Gunma University School of Medicine, Japan"
Journal Title:		Antimicrob Agents Chemother
Year:		1997
Volume:		41
Issue:		3
Page Number:		702 - 705
DOI:		10.1128/AAC.41.3.702
ISSN/ISBN:		0066-4804 (Print) 1098-6596 (Electronic) 0066-4804 (Linking)
Abstract:		"Eleven pheromone-responding plasmids encoding erythromycin or gentamicin resistance were isolated from multiresistant clinical Enterococcus faecalis isolates. The plasmids were classified into six types with respect to their pheromone responses. The three erythromycin resistance plasmids responded to different pheromones. Of the eight gentamicin resistance plasmids, four plasmids responded to same pheromone. Southern hybridization studies showed that the genes involved in regulation of the pheromone response were conserved in the drug resistance plasmids"
Keywords:		"Anti-Bacterial Agents/*pharmacology Blotting, Southern Chromosome Mapping Drug Resistance, Microbial Electrophoresis, Polyacrylamide Gel Enterococcus faecalis/*genetics Gentamicins/*pharmacology Gram-Positive Bacterial Infections/microbiology Humans Phero;"
Notes:		"MedlineShiojima, M Tomita, H Tanimoto, K Fujimoto, S Ike, Y eng Research Support, Non-U.S. Gov't 1997/03/01 Antimicrob Agents Chemother. 1997 Mar; 41(3):702-5. doi: 10.1128/AAC.41.3.702"