| Title: | "Comparison of signal-to-noise, blank determination, and linear regression methods for the estimation of detection and quantification limits for volatile organic compounds by gas chromatography" |
| Author(s): | Sanagi MM; Ling SL; Nasir Z; Hermawan D; Ibrahim WA; Abu Naim A; |
| Address: | "Universiti Teknologi Malaysia, Department of Chemistry, Faculty of Science, 81310 UTM Skudai, Johor, Malaysia. marsin@kimia.fs.utm.my" |
| ISSN/ISBN: | 1060-3271 (Print) 1060-3271 (Linking) |
| Abstract: | "LOD and LOQ are two important performance characteristics in method validation. This work compares three methods based on the International Conference on Harmonization and EURACHEM guidelines, namely, signal-to-noise, blank determination, and linear regression, to estimate the LOD and LOQ for volatile organic compounds (VOCs) by experimental methodology using GC. Five VOCs, toluene, ethylbenzene, isopropylbenzene, n-propylbenzene, and styrene, were chosen for the experimental study. The results indicated that the estimated LODs and LOQs were not equivalent and could vary by a factor of 5 to 6 for the different methods. It is, therefore, essential to have a clearly described procedure for estimating the LOD and LOQ during method validation to allow interlaboratory comparisons" |
| Keywords: | "Algorithms Chromatography, Gas Data Interpretation, Statistical Indicators and Reagents Least-Squares Analysis Linear Models Organic Chemicals/*analysis Reference Standards;" |
| Notes: | "MedlineSanagi, M Marsin Ling, Susie L Nasir, Zalilah Hermawan, Dadan Ibrahim, Wan Aini Wan Abu Naim, Ahmedy eng Comparative Study Research Support, Non-U.S. Gov't England 2010/02/20 J AOAC Int. 2009 Nov-Dec; 92(6):1833-8" |
