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PLoS One

Title:		Moonlighting peptides with emerging function
Author(s):		Rodriguez Plaza JG; Villalon Rojas A; Herrera S; Garza-Ramos G; Torres Larios A; Amero C; Zarraga Granados G; Gutierrez Aguilar M; Lara Ortiz MT; Polanco Gonzalez C; Uribe Carvajal S; Coria R; Pena Diaz A; Bredesen DE; Castro-Obregon S; Del Rio G;
Address:		"Biochemistry and Structural Biology Department, Instituto de Fisiologia Celular, Universidad Nacional Autonoma de Mexico, Mexico DF, Mexico"
Journal Title:		PLoS One
Year:		2012
Volume:		20120713
Issue:		7
Page Number:		e40125 -
DOI:		10.1371/journal.pone.0040125
ISSN/ISBN:		1932-6203 (Electronic) 1932-6203 (Linking)
Abstract:		"Hunter-killer peptides combine two activities in a single polypeptide that work in an independent fashion like many other multi-functional, multi-domain proteins. We hypothesize that emergent functions may result from the combination of two or more activities in a single protein domain and that could be a mechanism selected in nature to form moonlighting proteins. We designed moonlighting peptides using the two mechanisms proposed to be involved in the evolution of such molecules (i.e., to mutate non-functional residues and the use of natively unfolded peptides). We observed that our moonlighting peptides exhibited two activities that together rendered a new function that induces cell death in yeast. Thus, we propose that moonlighting in proteins promotes emergent properties providing a further level of complexity in living organisms so far unappreciated"
Keywords:		"Amino Acid Sequence Anti-Bacterial Agents/pharmacology Antifungal Agents/pharmacology Microbial Sensitivity Tests Mitochondrial Swelling/drug effects Molecular Sequence Data Peptides/chemistry/*pharmacology Pheromones/pharmacology Protein Structure, Secon;"
Notes:		"MedlineRodriguez Plaza, Jonathan G Villalon Rojas, Amanda Herrera, Sur Garza-Ramos, Georgina Torres Larios, Alfredo Amero, Carlos Zarraga Granados, Gabriela Gutierrez Aguilar, Manuel Lara Ortiz, Maria Teresa Polanco Gonzalez, Carlos Uribe Carvajal, Salvador Coria, Roberto Pena Diaz, Antonio Bredesen, Dale E Castro-Obregon, Susana del Rio, Gabriel eng Research Support, Non-U.S. Gov't 2012/07/19 PLoS One. 2012; 7(7):e40125. doi: 10.1371/journal.pone.0040125. Epub 2012 Jul 13"