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Antimicrob Agents Chemother


Title:"A novel engineered peptide, a narrow-spectrum antibiotic, is effective against vancomycin-resistant Enterococcus faecalis"
Author(s):Qiu XQ; Zhang J; Wang H; Wu GY;
Address:"Laboratory of Biomembrane and Membrane Protein, West China Hospital, Chengdu, People's Republic of China"
Journal Title:Antimicrob Agents Chemother
Year:2005
Volume:49
Issue:3
Page Number:1184 - 1189
DOI: 10.1128/AAC.49.3.1184-1189.2005
ISSN/ISBN:0066-4804 (Print) 1098-6596 (Electronic) 0066-4804 (Linking)
Abstract:"A novel antienterococcal peptide was prepared by fusing the enterococcal cCF10 pheromone to the channel-forming domain of colicin Ia, forming Enterococcus faecalis pheromonicin (PMC-EF). This peptide was bactericidal against vancomycin-resistant Enterococcus faecalis (VRE) organisms. Electron microscopy and vital dyes confirmed increased membrane permeability. All mice made bacteremic with VRE strains survived when they were treated with PMC-EF, while all controls died"
Keywords:Anti-Bacterial Agents/*pharmacology Base Sequence Colicins/pharmacology Enterococcus faecalis/*drug effects Microbial Sensitivity Tests Molecular Sequence Data *Peptides Protein Engineering *Vancomycin Resistance;
Notes:"MedlineQiu, Xiao-Qing Zhang, Jie Wang, He Wu, George Y eng R01 DK042182/DK/NIDDK NIH HHS/ Research Support, Non-U.S. Gov't 2005/02/25 Antimicrob Agents Chemother. 2005 Mar; 49(3):1184-9. doi: 10.1128/AAC.49.3.1184-1189.2005"

 
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