| Title: | Metabolomic Analysis of Respiratory Epithelial Lining Fluid in Patients with Chronic Obstructive Pulmonary Disease-A Systematic Review |
| Author(s): | Pulik K; Mycroft K; Korczynski P; Ciechanowicz AK; Gorska K; |
| Address: | "Department of Internal Medicine, Pulmonary Diseases and Allergy, Medical University of Warsaw, Banacha 1A, 02-097 Warsaw, Poland. Laboratory of Regenerative Medicine, Medical University of Warsaw, Banacha 1B, 02-097 Warsaw, Poland" |
| ISSN/ISBN: | 2073-4409 (Electronic) 2073-4409 (Linking) |
| Abstract: | "Chronic obstructive pulmonary disease (COPD), as the third leading cause of death among adults, is a significant public health problem around the world. However, about 75% of smokers do not develop the disease despite the severe smoking burden. COPD is a heterogeneous disease, and several phenotypes, with differences in their clinical picture and response to treatment, have been distinguished. Metabolomic studies provide information on metabolic pathways, and therefore are a promising tool for understanding disease etiopathogenesis and the development of effective causal treatment. The aim of this systematic review was to analyze the metabolome of the respiratory epithelial lining fluid of patients with COPD, compared to healthy volunteers, refractory smokers, and subjects with other lung diseases. We included observational human studies. Sphingolipids, phosphatidylethanolamines, and sphingomyelins distinguished COPD from non-smokers; volatile organic compounds, lipids, and amino acids distinguished COPD from smokers without the disease. Five volatile organic compounds were correlated with eosinophilia and four were associated with a phenotype with frequent exacerbations. Fatty acids and ornithine metabolism were correlated with the severity of COPD. Metabolomics, by searching for biomarkers and distinguishing metabolic pathways, can allow us to understand the pathophysiology of COPD and the development of its phenotypes" |
| Keywords: | "Adult Humans *Volatile Organic Compounds *Pulmonary Disease, Chronic Obstructive/metabolism Metabolomics Smoking Metabolome Balf Copd Ebc cigarette smoke induced sputum lipidomics metabolic alterations;" |
| Notes: | "MedlinePulik, Kaja Mycroft, Katarzyna Korczynski, Piotr Ciechanowicz, Andrzej K Gorska, Katarzyna eng Research Support, Non-U.S. Gov't Review Systematic Review Switzerland 2023/03/30 Cells. 2023 Mar 8; 12(6):833. doi: 10.3390/cells12060833" |
