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Neurosci Lett

Title:		Intrabulbar infusions of (+/-)S-nitroso-N-acetylpenicillamine and L-arginine induce functional plasticity in the accessory olfactory bulb of female mice
Author(s):		Okere CO; Kaba H; Takahashi S; Higuchi T;
Address:		"Department of Physiology, Kochi Medical School, Japan. okerec@dtn.am400gw.kochi-ms.ac.jp"
Journal Title:		Neurosci Lett
Year:		1996
Volume:		217
Issue:		2-Mar
Page Number:		197 - 199
DOI:
ISSN/ISBN:		0304-3940 (Print) 0304-3940 (Linking)
Abstract:		"Infusions of a nitrosothiol, (+/-)S-nitroso-N-acetylpenicillamine or L-arginine into the accessory olfactory bulb (AOB) are capable of causing memory or learning-related synaptic plasticity in female mice. This is consistent with the ability of nitric oxide (NO), released spontaneously or by activation of the endogenous synthesizing system, to enhance a long-lasting increase in gain of AOB synapses; resulting in memory formation for male pheromones without mating. Hemoglobin, a NO scavenger, prevented this memory suggesting, in part, an extracellular action of NO in this functional plasticity"
Keywords:		"Animals Arginine/administration & dosage/*pharmacology Female Hemoglobins/pharmacology Learning/drug effects Memory/drug effects Mice Mice, Inbred BALB C Microinjections Neuronal Plasticity/*drug effects Nitric Oxide/biosynthesis Olfactory Bulb/drug effec;"
Notes:		"MedlineOkere, C O Kaba, H Takahashi, S Higuchi, T eng Research Support, Non-U.S. Gov't Ireland 1996/10/18 Neurosci Lett. 1996 Oct 18; 217(2-3):197-9"