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Curr Gastroenterol Rep

Title:		Innovations in Screening Tools for Barrett's Esophagus and Esophageal Adenocarcinoma
Author(s):		Bell MG; Iyer PG;
Address:		"Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA. Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA. Iyer.Prasad@mayo.edu"
Journal Title:		Curr Gastroenterol Rep
Year:		2021
Volume:		20211015
Issue:		12
Page Number:		22 -
DOI:		10.1007/s11894-021-00821-6
ISSN/ISBN:		1534-312X (Electronic) 1522-8037 (Linking)
Abstract:		"PURPOSE OF REVIEW: Esophageal adenocarcinoma (EAC) is a lethal disease with rapidly rising incidence. Screening for EAC and its metaplastic precursor, Barrett's esophagus (BE), followed by endoscopic surveillance and endoscopic treatment of dysplasia or early EAC are promising approaches to decreasing EAC incidence and EAC mortality. Historically, screening for EAC has been completed with a traditional per-oral esophagogastroduodenoscopy (EGD); however, this method has limitations including cost, tolerability, and accessibility. For this reason, much effort has been put forward to develop more effective, minimally invasive, and accessible BE and EAC screening tools. The purpose of this review is to describe recent developments of these novel tools. RECENT FINDINGS: While endoscopic alternatives such as transnasal endoscopy are cheaper and well tolerated, they have not gained acceptance. Non-endoscopic modalities namely, swallowable cell collection devices coupled with biomarker analysis have been found to have excellent performance characteristics, tolerability, and cost effectiveness. In this article, we provide an update on innovative developments in EAC/BE screening modalities including transnasal endoscopy, capsule endomicroscopy, swallowable cell collection devices, and exhaled volatile organic compound analyses"
Keywords:		"*Adenocarcinoma/diagnosis/prevention & control *Barrett Esophagus/diagnosis Endoscopy, Digestive System *Esophageal Neoplasms/diagnosis/prevention & control Humans Mass Screening Barrett's Esophagus Esophageal Adenocarcinoma Screening;"
Notes:		"MedlineBell, Matthew G Iyer, Prasad G eng CA241164/Foundation for the National Institutes of Health/ Review 2021/10/17 Curr Gastroenterol Rep. 2021 Oct 15; 23(12):22. doi: 10.1007/s11894-021-00821-6"