« Previous Abstract"Effect of Quillaja saponaria dietary administration on colour, oxidative stability and volatile profile of muscle longissimus dorsi of Barbarine lamb"    Next AbstractCharacterization of the Erwinia chrysanthemi expI-expR locus directing the synthesis of two N-acyl-homoserine lactone signal molecules »

Proteomics

Title:		Nanomaterials in the Environment Acquire an 'Eco-Corona' Impacting their Toxicity to Daphnia Magna-a Call for Updating Toxicity Testing Policies
Author(s):		Nasser F; Constantinou J; Lynch I;
Address:		"School of Geography, Earth and Environmental Sciences, University of Birmingham, Edgbaston, B15 2TT, Birmingham, UK. School of Biosciences, University of Birmingham, Edgbaston, B15 2TT, Birmingham, UK"
Journal Title:		Proteomics
Year:		2020
Volume:		20191206
Issue:		9
Page Number:		e1800412 -
DOI:		10.1002/pmic.201800412
ISSN/ISBN:		1615-9861 (Electronic) 1615-9853 (Linking)
Abstract:		"Nanomaterials (NMs) are particles with at least one dimension between 1 and 100 nm and a large surface area to volume ratio, providing them with exceptional qualities that are exploited in a variety of industrial fields. Deposition of NMs into environmental waters during or after use leads to the adsorption of an ecological (eco-) corona, whereby a layer of natural biomolecules coats the NM changing its stability, identity and ultimately toxicity. The eco-corona is not currently incorporated into ecotoxicity tests, although it has been shown to alter the interactions of NMs with organisms such as Daphnia magna (D. magna). Here, the literature on environmental biomolecule interactions with NMs is synthesized and a framework for understanding the eco-corona composition and its role in modulating NMs ecotoxicity is presented, utilizing D. magna as a model. The importance of including biomolecules as part of the current international efforts to update the standard testing protocols for NMs, is highlighted. Facilitating the formation of an eco-corona prior to NMs ecotoxicity testing will ensure that signaling pathways perturbed by the NMs are real rather than being associated with the damage arising from reactive NM surfaces 'acquiring' a corona by pulling biomolecules from the organism's surface"
Keywords:		"Adsorption Animals Daphnia/*drug effects/*metabolism Nanostructures/*chemistry/*toxicity Pheromones/metabolism Toxicity Tests/*methods Water Pollutants, Chemical/chemistry/pharmacokinetics/toxicity bio-nano interface biomolecule corona ecological corona e;"
Notes:		"MedlineNasser, Fatima Constantinou, Julia Lynch, Iseult eng Research Support, Non-U.S. Gov't Review Germany 2019/11/22 Proteomics. 2020 May; 20(9):e1800412. doi: 10.1002/pmic.201800412. Epub 2019 Dec 6"