| Title: | Alterations in interleukin-4 and antibody production following pheromone exposure: role of glucocorticoids |
| Author(s): | Moynihan JA; Karp JD; Cohen N; Cocke R; |
| Address: | "Department of Psychiatry, University of Rochester Medical Center, NY 14642" |
| DOI: | 10.1016/0165-5728(94)90230-5 |
| ISSN/ISBN: | 0165-5728 (Print) 0165-5728 (Linking) |
| Abstract: | "We have previously shown that exposure to pheromones from footshock-stressed mice suppresses cell-mediated immunity and enhances humoral immunity. Here we show that stress odor exposure is associated with enhanced antigen-specific antibody production and interleukin (IL)-4 production in BALB/c, but not C57Bl/6, mice. Glucocorticoid receptor antagonism blocks the enhancement of IL-4, but not antibody titers. There is an apparent differential sensitivity of BALB/c and C57Bl/6 spleen cells to in vitro incubation with the synthetic glucocorticoid dexamethasone; IL-2 production by BALB/c spleen cells is more sensitive to the effects of steroid. These data suggest that C57Bl/6 mice may not respond to stress pheromones due to their relative insensitivity to endogenous steroids" |
| Keywords: | "Animals Antibody Formation/drug effects Antigens/immunology Concanavalin A/pharmacology Dexamethasone/*pharmacology Drug Implants Hemocyanins/immunology Interleukin-4/*biosynthesis Male Mice Mice, Inbred BALB C Mice, Inbred C57BL Mifepristone/pharmacology;" |
| Notes: | "MedlineMoynihan, J A Karp, J D Cohen, N Cocke, R eng MH42051/MH/NIMH NIH HHS/ MH45681/MH/NIMH NIH HHS/ T32 MH18822/MH/NIMH NIH HHS/ Research Support, U.S. Gov't, P.H.S. Netherlands 1994/10/01 J Neuroimmunol. 1994 Oct; 54(1-2):51-8. doi: 10.1016/0165-5728(94)90230-5" |
