| Title: | The electronic nose in respiratory medicine |
| Author(s): | Montuschi P; Mores N; Trove A; Mondino C; Barnes PJ; |
| Address: | "Department of Pharmacology, Faculty of Medicine, Catholic University of the Sacred Heart, Rome, Italy. pmontuschi@rm.unicatt.it" |
| ISSN/ISBN: | 1423-0356 (Electronic) 0025-7931 (Linking) |
| Abstract: | "Several volatile organic compounds have been identified in exhaled breath in healthy subjects and patients with respiratory diseases by gas chromatography/mass spectrometry. Identification of selective patterns of volatile organic compounds in exhaled breath could be used as a biomarker of inflammatory lung diseases. An electronic nose (e-nose) is an artificial sensor system that generally consists of an array of chemical sensors for detection of volatile organic compound profiles (breathprints) and an algorithm for pattern recognition. E-noses are handheld, portable devices that provide immediate results. E-noses discriminate between patients with respiratory disease, including asthma, COPD and lung cancer, and healthy control subjects, and also among patients with different respiratory diseases. E-nose breathprints are associated with airway inflammation activity. In combination with other 'omics' platforms, e-nose technology might contribute to the identification of new surrogate markers of pulmonary inflammation and subphenotypes of patients with respiratory diseases, provide a molecular basis to a personalized pharmacological treatment, and facilitate the development of new drugs" |
| Keywords: | *Electronic Nose Humans Pulmonary Medicine/*methods Respiratory Tract Diseases/*rehabilitation; |
| Notes: | "MedlineMontuschi, Paolo Mores, Nadia Trove, Andrea Mondino, Chiara Barnes, Peter J eng Research Support, Non-U.S. Gov't Review Switzerland 2012/09/29 Respiration. 2013; 85(1):72-84. doi: 10.1159/000340044. Epub 2012 Sep 25" |
