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Neuroscience

Title:		Expression and regulation of the immediate-early gene product Arc in the accessory olfactory bulb after mating in male rat
Author(s):		Matsuoka M; Yamagata K; Sugiura H; Yoshida-Matsuoka J; Norita M; Ichikawa M;
Address:		"Division of Neurobiology and Anatomy, Niigata University Graduate School of Medical and Dental Sciences, Japan. winner@med.niigata-u.ac.jp"
Journal Title:		Neuroscience
Year:		2002
Volume:		111
Issue:		2
Page Number:		251 - 258
DOI:		10.1016/s0306-4522(01)00620-0
ISSN/ISBN:		0306-4522 (Print) 0306-4522 (Linking)
Abstract:		"Recent studies of the accessory olfactory bulb have shown that the expression of immediate-early genes, e.g., c-fos, c-jun and egr-1, can be used as a marker of neuronal activity in response to pheromonal cues. In this study, we analyzed the expression pattern, in response to mating, of the novel immediate-early gene product Arc (an activity-regulated cytoskeleton-associated protein). Arc is hypothesized to play a role in activity-dependent neuronal plasticity in the hippocampus. In a control group of male rats, only a small number of Arc-immunoreactive cells were observed in the accessory olfactory bulb. In a mating group, however, a marked increase in the number of Arc-immunoreactive cells was observed only in the granule cell layer of the accessory olfactory bulb. The increase in the number of Arc-immunoreactive cells after mating was similar to that observed for other immediate-early genes. However, for the mating group, the increase in Arc-positive cells was limited to the granule cell layer. Granule cells have been shown to exhibit a strong synaptic plasticity in response to pheromonal stimulation. From these findings we suggest that Arc plays an important role in neuronal plasticity in the accessory olfactory bulb"
Keywords:		Animals Copulation/*physiology Cytoskeletal Proteins Denervation *Gene Expression Immediate-Early Proteins/*genetics/metabolism Immunoblotting Immunohistochemistry Male *Nerve Tissue Proteins Olfactory Bulb/*physiology Proto-Oncogene Proteins c-fos/metabo;neuroscience;
Notes:		"MedlineMatsuoka, Masato Yamagata, Kanato Sugiura, Hiroko Yoshida-Matsuoka, Junko Norita, Masao Ichikawa, Masumi eng Research Support, Non-U.S. Gov't 2002/05/02 Neuroscience. 2002; 111(2):251-8. doi: 10.1016/s0306-4522(01)00620-0"