| Title: | Current Perspectives on Uniparental Mitochondrial Inheritance in Cryptococcus neoformans |
| Address: | "Department of Microbiology, University of Georgia, Athens, GA 30602, USA" |
| ISSN/ISBN: | 2076-0817 (Print) 2076-0817 (Electronic) 2076-0817 (Linking) |
| Abstract: | "The mitochondrion is a vital organelle in most eukaryotic cells. It contains its own DNA which differs from nuclear DNA, since it is often inherited from only one parent during sexual reproduction. In anisogamous mammals, this is largely due to the fact that the oocyte has over 1000 times more copies of mitochondrial DNA than the sperm. However, in the isogamous fungus Cryptococcus neoformans, uniparental mitochondrial inheritance (UMI) still occurs during sexual reproduction. It is proposed that UMI might have evolved in the last common ancestor of eukaryotes. Thus, understanding the fundamental process of UMI in lower eukaryotes may give insights into how the process might have evolved in eukaryotic ancestors. In this review, we discuss the current knowledge regarding the cellular features as well as the molecular underpinnings of UMI in Cryptococcus during the mating process, and open questions that need to be answered to solve the mystery of UMI in this eukaryotic microbe" |
| Keywords: | Cryptococcus neoformans bisexual reproduction mating pheromone sensing pathway uniparental mitochondrial inheritance; |
| Notes: | "PubMed-not-MEDLINEMatha, Amber R Lin, Xiaorong eng R01 AI140719/AI/NIAID NIH HHS/ R01AI140719/NH/NIH HHS/ Startup/University of Georgia/ Review Switzerland 2020/09/16 Pathogens. 2020 Sep 10; 9(9):743. doi: 10.3390/pathogens9090743" |
