| Title: | Indoor exposure to particulate matter and volatile organic compounds in dwellings and workplaces and respiratory health in French farmers |
| Author(s): | Maesano CN; Caillaud D; Youssouf H; Banerjee S; Prud'Homme J; Audi C; Horo K; Toloba Y; Ramousse O; Annesi-Maesano I; |
| Address: | "1Epidemiology of Allergic and Respiratory diseases department (EPAR), Institut Pierre Louis d'Epidemiologie et de Sante Publique, INSERM, Sorbonne Universite, Medical School St Antoine, 27 rue Chaligny, 75571 Paris CEDEX 12, France. ISNI: 0000 0001 2308 1657. GRID: grid.462844.8 2Service de Pneumologie, Hopital Gabriel Montpied, CHU Clermont-Ferrand, Clermont-Ferrand, France. ISNI: 0000 0004 0639 4151. GRID: grid.411163.0 3Intensive Care Unit and Respiratory Diseases Department, CHU, Cocody, Abidjan, Cote d'Ivoire. GRID: grid.411387.8 Service de pneumologie, CHU du Point-G, Bamako, E1631 Mali. Mutuelle Salaries Agricoles, Clermont-Ferrand, France" |
| DOI: | 10.1186/s40248-019-0194-3 |
| ISSN/ISBN: | 1828-695X (Print) 2049-6958 (Electronic) 1828-695X (Linking) |
| Abstract: | "INTRODUCTION: Few investigations have related objective assessments of indoor air pollutants to respiratory health in farmers, in spite of the many rural environmental hazards to which they are exposed. Chemical air pollution has been particularly neglected. OBJECTIVE: We investigated the relationships of indoor exposure to particulate matter (PM) and volatile organic compounds (VOCs) to respiratory health in farmers. METHODS: Nineteen VOCs (5 families) and PM (from ultrafine to total suspended particles (TSP)) were objectively assessed in dwellings and workplaces in 109 French farmers during a week. To take into account multiple exposures, scores of exposure were computed for total VOCs and VOCs families. Individuals filled a standardized questionnaire and underwent spirometry with bronchodilation test. RESULTS: On average, VOCs concentrations were higher in dwellings than in workplaces. The reverse was observed for PM. When considering the mean concentrations of air pollutants for the whole farm (dwellings + workplaces), asthma (9.3%) was positively associated with elevated exposure to benzene (adjusted odds-ratio (ORa) = 6.64, 95%CI: 1.56-28.27), trichloroethylene (4.80, 1.00-23.30) and halogenated hydrocarbons score (2.9, 95% 1.3-6.8). Early airway obstruction (FEF(25-75) < 80%, with normal FEV(1) and FVC and FEV/FVC >/= 70%) (29.8%) was related to elevated exposure to 2-butoxyetylacetate (11.49, 1.55-85.37) and glycol ethers score (2.0; 1.0-4.1) in the whole farm and to PM(2.5) (ORa = 5.26, 95% CI: 1.09-25.28) in the granary/stable. The risk of Chronic Obstructive Pulmonary Diseases (FEV/FVC < 70%) (COPD) (4.26%) was found to be larger with elevated exposure to aldehydes (OR = 3.95, 1.09-14.26). CONCLUSION: Indoor chemical air pollution is detrimental to farmers' respiratory health. More epidemiological investigations with detailed exposure assessments and clinical measures of respiratory effects are needed in rural settings to corroborate these findings" |
| Keywords: | Air chemicals Asthma Chronic obstructive pulmonary disease Early airway obstruction Multipollution Rural Total suspended particles Ultrafine particles Voc VOCs score; |
| Notes: | "PubMed-not-MEDLINEMaesano, Cara Nichole Caillaud, Denis Youssouf, Hassani Banerjee, Soutrik Prud'Homme, Julie Audi, Christelle Horo, Kigninlman Toloba, Yacouba Ramousse, Ollivier Annesi-Maesano, Isabella eng Italy 2019/10/09 Multidiscip Respir Med. 2019 Oct 2; 14:33. doi: 10.1186/s40248-019-0194-3. eCollection 2019" |
