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Environ Sci Pollut Res Int

Title:		"Fosthiazate exposure induces oxidative stress, nerve damage, and reproductive disorders in nontarget nematodes"
Author(s):		Liu S; Wu Q; Zhong Y; He Z; Wang Z; Li R; Wang M;
Address:		"Department of Pesticide Science, College of Plant Protection, State & Local Joint Engineering Research Center of Green Pesticide Invention and Application, Nanjing Agricultural University, No. 1 Weigang Road, Nanjing, 210095, Jiangsu province, China. Department of Pesticide Science, College of Plant Protection, State & Local Joint Engineering Research Center of Green Pesticide Invention and Application, Nanjing Agricultural University, No. 1 Weigang Road, Nanjing, 210095, Jiangsu province, China. wangmha@njau.edu.cn"
Journal Title:		Environ Sci Pollut Res Int
Year:		2023
Volume:		20220916
Issue:		5
Page Number:		12522 - 12531
DOI:		10.1007/s11356-022-23010-y
ISSN/ISBN:		1614-7499 (Electronic) 0944-1344 (Linking)
Abstract:		"As a forceful nematicide, fosthiazate has been largely applied in the management of root-knot nematodes and other herbivorous nematodes. However, the toxicity of fosthiazate to nontarget nematodes is unclear. To explore the toxicity and the mechanisms of fosthiazate in nontarget nematodes, Caenorhabditis elegans was exposed to 0.01-10 mg/L fosthiazate. The results implied that treatment with fosthiazate at doses above 0.01 mg/L could cause injury to the growth, locomotion behavior, and reproduction of the nematodes. Moreover, L1 larvae were more vulnerable to fosthiazate exposure than L4 larvae. Reactive oxygen species (ROS) production and lipofuscin accumulation were fairly increased in 1 mg/L fosthiazate-exposed nematodes. Treatment with 0.1 mg/L fosthiazate significantly inhibited the activity of acetylcholinesterase (p < 0.01). Furthermore, subacute exposure to 10 mg/L fosthiazate strongly influenced the expression of genes related to oxidative stress, reproduction, and nerve function (e.g., gst-1, sod-1, puf-8, wee-1.3, and ace-1 genes). These findings suggested that oxidative stress, reproduction and nerve disorders could serve as key endpoints of toxicity induced by fosthiazate. The cyp-35a family gene was the main metabolic fosthiazate in C. elegans, and the cyp-35a5 subtype was the most sensitive, with a change in expression level of 2.11-fold compared with the control. These results indicate that oxidative stress and neurological and reproductive disorders played fundamental roles in the toxicity of fosthiazate in C. elegans and may affect the abundance and function of soil nematodes"
Keywords:		Animals *Caenorhabditis elegans/physiology *Caenorhabditis elegans Proteins/genetics/metabolism Acetylcholinesterase/metabolism Oxidative Stress Reactive Oxygen Species/metabolism Reproduction Protein-Tyrosine Kinases/metabolism Protein Serine-Threonine K;
Notes:		"MedlineLiu, Shiling Wu, Qiqi Zhong, Yanru He, Zongzhe Wang, Zhen Li, Rui Wang, Minghua eng Germany 2022/09/17 Environ Sci Pollut Res Int. 2023 Jan; 30(5):12522-12531. doi: 10.1007/s11356-022-23010-y. Epub 2022 Sep 16"