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Eur Biophys J

Title:		Ligand-receptor interaction under periodic stimulation: a modeling study of concentration chemoreceptors
Author(s):		Lansky P; Krivan V; Rospars JP;
Address:		"Institute of Physiology, Academy of Sciences of Czech Republic, Prague. lansky@biomed.cas.cz"
Journal Title:		Eur Biophys J
Year:		2001
Volume:		30
Issue:		2
Page Number:		110 - 120
DOI:		10.1007/s002490100142
ISSN/ISBN:		0175-7571 (Print) 0175-7571 (Linking)
Abstract:		"The first step of chemosensory transduction consists in the association of ligand molecules with receptor proteins borne by the cell membrane. In this article, the time evolution of ligand-receptor complexes is studied in the presence of a periodically changing ligand concentration. This type of stimulation is a close approximation to some natural situations, for example in olfaction. The transient and steady-state periodic levels of the complexes, resulting from a single-step (binding) or double-step (binding and activation) reaction, are determined. When possible, analytical solutions are given, if not for the complete model, at least for its simplified version at low ligand concentration. Otherwise, solutions are found numerically and both the complete and simplified versions of the model are compared. The results obtained are discussed with respect to actual experimental data based on the moth sex-pheromone receptor. Periodic steady states are achieved very quickly and their amplitude decreases when the stimulation frequency increases. We show that the simplified description is adequate if only a fraction of activated receptors is sufficient to produce the maximum response, as is actually the case in the example treated. The role of the frequency of stimulation is investigated and it is shown to possess an optimal range between 2 and 5 Hz"
Keywords:		"Animals Cell Membrane/physiology Chemoreceptor Cells/*physiology Kinetics *Ligands Models, Biological Models, Neurological Neurons/physiology Olfactory Pathways/physiology Olfactory Receptor Neurons/physiology Signal Transduction;"
Notes:		"MedlineLansky, P Krivan, V Rospars, J P eng Research Support, Non-U.S. Gov't Germany 2001/06/21 Eur Biophys J. 2001; 30(2):110-20. doi: 10.1007/s002490100142"