| Title: | A human protein specific for the immunoglobulin octamer DNA motif contains a functional homeobox domain |
| Author(s): | Ko HS; Fast P; McBride W; Staudt LM; |
| Address: | "Metabolism Branch, National Cancer Institute, Bethesda, Maryland 20892" |
| DOI: | 10.1016/0092-8674(88)90016-5 |
| ISSN/ISBN: | 0092-8674 (Print) 0092-8674 (Linking) |
| Abstract: | "The homeobox domain is shared by Drosophila homeotic proteins, yeast mating type proteins, and some functionally uncharacterized mammalian proteins. A lymphoid-restricted human protein that binds to the immunoglobulin octamer regulatory motif was shown to contain an amino acid sequence that has 33% amino acid identity with the consensus sequence of the previously cloned homebox domains. This homeobox gene was localized to chromosome 19, thus mapping separately from other human homebox genes. A mutant protein containing amino acid substitutions within a putative helix-turn-helix motif in the homeobox domain did not bind DNA detectably. This human homeobox protein was shown to bind the same DNA sequence as the homeobox domains of the yeast mating type proteins and Drosophila homeotic protein, suggesting that homeobox proteins may have closely related DNA binding characteristics" |
| Keywords: | "Amino Acid Sequence Animals Base Sequence DNA/*analysis Genes, Fungal *Genes, Homeobox Genes, Mating Type, Fungal Humans Immunoglobulins/*genetics Mating Factor Molecular Sequence Data Peptides/genetics;" |
| Notes: | "MedlineKo, H S Fast, P McBride, W Staudt, L M eng Comparative Study 1988/10/07 Cell. 1988 Oct 7; 55(1):135-44. doi: 10.1016/0092-8674(88)90016-5" |
