| Title: | Mechanisms controlling diversification of olfactory sensory neuron classes |
| Author(s): | Hsieh YW; Alqadah A; Chuang CF; |
| Address: | "Department of Biological Sciences, University of Illinois at Chicago, 900 S. Ashland Avenue, MC 567, Chicago, IL, 60607, USA. Department of Biological Sciences, University of Illinois at Chicago, 900 S. Ashland Avenue, MC 567, Chicago, IL, 60607, USA. chioufen.chuang@gmail.com" |
| DOI: | 10.1007/s00018-017-2512-2 |
| ISSN/ISBN: | 1420-9071 (Electronic) 1420-682X (Print) 1420-682X (Linking) |
| Abstract: | "Animals survive in harsh and fluctuating environments using sensory neurons to detect and respond to changes in their surroundings. Olfactory sensory neurons are essential for detecting food, identifying danger, and sensing pheromones. The ability to sense a large repertoire of different types of odors is crucial to distinguish between different situations, and is achieved through neuronal diversity within the olfactory system. Here, we review the developmental mechanisms used to establish diversity of olfactory sensory neurons in various model organisms, including Caenorhabditis elegans, Drosophila, and vertebrate models. Understanding and comparing how different olfactory neurons develop within the nervous system of different animals can provide insight into how the olfactory system is shaped in humans" |
| Keywords: | "Animals Cell Communication Enhancer Elements, Genetic/genetics Epigenesis, Genetic Olfactory Receptor Neurons/classification/*metabolism Receptors, Notch/metabolism Receptors, Odorant/genetics/metabolism Smell/physiology Transcription Factors/metabolism C;" |
| Notes: | "MedlineHsieh, Yi-Wen Alqadah, Amel Chuang, Chiou-Fen eng R01 GM098026/GM/NIGMS NIH HHS/ Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review Switzerland 2017/03/31 Cell Mol Life Sci. 2017 Sep; 74(18):3263-3274. doi: 10.1007/s00018-017-2512-2. Epub 2017 Mar 29" |
