| Title: | Breath volatile organic compounds and inflammatory markers in adult asthma patients: negative results from the ALLIANCE cohort |
| Author(s): | Holz O; Waschki B; Watz H; Kirsten A; Abdo M; Pedersen F; Weckmann M; Fuchs O; Dittrich AM; Hansen G; Kopp MV; von Mutius E; Rabe KF; Hohlfeld JM; Bahmer T; Group AS; |
| Address: | "Fraunhofer ITEM, Hannover, Germany. German Center for Lung Research, BREATH. O. Holz and B. Waschki contributed equally. University Hospital Hamburg-Eppendorf, Department of Cardiology, University Heart and Vascular Center Hamburg, Hamburg, Germany. LungenClinic Grosshansdorf, Grosshansdorf, Germany. German Center for Lung Research, ARCN. Pulmonary Research Institute at LungenClinic Grosshansdorf, Grosshansdorf, Germany. Division of Pediatric Pulmonology and Allergology, University Children's Hospital, Luebeck, Germany. Dept of Paediatric Respiratory Medicine, Inselspital, University Children's Hospital of Bern, University of Bern, Bern, Switzerland. German Center for Lung Research, CPC-M. Dept of Paediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany. Dr von Hauner Children's Hospital, Ludwig Maximilians University, Munich, Germany. Department of Respiratory Medicine, Hannover Medical School, Hannover, Germany. J.M. Hohlfeld and T. Bahmer contributed equally. University Hospital Schleswig-Holstein, Campus Kiel, Internal Medicine Department I, Pneumology, Kiel, Germany" |
| DOI: | 10.1183/13993003.02127-2020 |
| ISSN/ISBN: | 1399-3003 (Electronic) 0903-1936 (Print) 0903-1936 (Linking) |
| Abstract: | "Despite recent publications, we are not close to finding a clinically valuable breath VOC biomarker for asthma or asthma phenotypes https://bit.ly/3heTgtK 'Breathomics' in asthma is a rapidly growing area of significant scientific interest, as indicated by a recently published review, two research articles, and their accompanying editorials in high impact pneumology journals [1-5]. The repeatedly observed associations between breath volatile organic compounds (VOCs) and sputum or blood inflammatory cells [2, 3] suggest that breathomics are on the brink of introduction as a valuable clinically tool. However, there are also major concerns about unresolved methodological issues and a general paucity of high-quality data [1, 6]. In this letter we detail our concerns with breathomics based on data from a cohort of adult asthma patients with a broad spectrum of clinical phenotypes. eng" |
| Keywords: | Adult *Asthma Biomarkers Breath Tests Exhalation Humans Negative Results *Volatile Organic Compounds; |
| Notes: | "MedlineHolz, Olaf Waschki, Benjamin Watz, Henrik Kirsten, Anne Abdo, Mustafa Pedersen, Frauke Weckmann, Markus Fuchs, Oliver Dittrich, Anna-Maria Hansen, Gesine Kopp, Matthias V von Mutius, Erika Rabe, Klaus F Hohlfeld, Jens M Bahmer, Thomas eng Letter Research Support, Non-U.S. Gov't England 2020/10/04 Eur Respir J. 2021 Feb 11; 57(2):2002127. doi: 10.1183/13993003.02127-2020. Print 2021 Feb" |
