| Title: | Hymenolepis diminuta (Cestoda) induces changes in expression of select genes of Tribolium confusum (Coleoptera) |
| Author(s): | Hitchen SJ; Shostak AW; Belosevic M; |
| Address: | "CW-405 Biological Sciences, University of Alberta, Edmonton, Alberta, Canada, T6G 2E9" |
| DOI: | 10.1007/s00436-009-1481-2 |
| ISSN/ISBN: | 1432-1955 (Electronic) 0932-0113 (Linking) |
| Abstract: | "The flour beetle Tribolium confusum is a common experimental intermediate host for the tapeworm Hymenolepis diminuta, but while many aspects of their host-parasite interactions have been determined to have genetic basis, the genes involved have not been identified. In this paper, we report on the expression of several predicted metabolic and defense-related genes using quantitative polymerase chain reaction 2 weeks after initial infection of the beetle. The expression of heat shock protein 68, a predicted sugar transporter, a pheromone binding protein, and endoglin were up-regulated in infected beetles. The expression of thaumatin-like protein and prophenoloxidase 2/3 was down-regulated in infected beetles, while the mRNA levels of Toll-like receptor 3, Toll-like receptor 4, and lysozyme 4 were not affected by infection with H. diminuta" |
| Keywords: | "Animals Gene Expression Profiling *Gene Expression Regulation *Host-Parasite Interactions Hymenolepis diminuta/*growth & development/*immunology RNA, Messenger/genetics Reverse Transcriptase Polymerase Chain Reaction/methods Tribolium/*immunology/*parasit;" |
| Notes: | "MedlineHitchen, Steven J Shostak, Allen W Belosevic, Miodrag eng Research Support, Non-U.S. Gov't Germany 2009/05/28 Parasitol Res. 2009 Sep; 105(3):875-9. doi: 10.1007/s00436-009-1481-2. Epub 2009 May 27" |
