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Insect Mol Biol

Title:		A cluster of four D7-related genes is expressed in the salivary glands of the African malaria vector Anopheles gambiae
Author(s):		Arca B; Lombardo F; Lanfrancotti A; Spanos L; Veneri M; Louis C; Coluzzi M;
Address:		"Dipartimento di Scienze di Sanita Pubblica, Universita di Roma 'La Sapienza' P.le Aldo Moro 5, 00185 Roma, Italy. b.arca@caspur.it"
Journal Title:		Insect Mol Biol
Year:		2002
Volume:		11
Issue:		1
Page Number:		47 - 55
DOI:		10.1046/j.0962-1075.2001.00309.x
ISSN/ISBN:		0962-1075 (Print) 0962-1075 (Linking)
Abstract:		"Four genes expressed in the Anopheles gambiae adult female salivary glands and similar in sequence to the Aedes aegypti D7 gene were identified. The genes, called D7-related (D7r), are included in a single cluster encompassing approximately six kilobases on chromosome arm 3R. The deduced proteins contain secretory signals and they are probably injected by the mosquito into the host with the saliva during blood feeding. The region of similarity to D7 encompasses the carboxy-terminal part of the Ae. aegypti protein and the different An. gambiae D7r show a degree of similarity to each other, varying from 53% to 73%. The weak but significant similarity to members of a wide family of insect proteins, including odourant- and pheromone-binding proteins, raises the possibility that the D7r-encoded proteins may bind and/or carry small hydrophobic ligands"
Keywords:		"Aedes/genetics Amino Acid Sequence Animals Anopheles/*genetics Base Sequence *Gene Expression *Genes, Insect Insect Vectors/*genetics Malaria Molecular Sequence Data *Multigene Family Salivary Glands Sequence Homology, Amino Acid;"
Notes:		"MedlineArca, B Lombardo, F Lanfrancotti, A Spanos, L Veneri, M Louis, C Coluzzi, M eng Research Support, Non-U.S. Gov't England 2002/02/14 Insect Mol Biol. 2002 Feb; 11(1):47-55. doi: 10.1046/j.0962-1075.2001.00309.x"