| Title: | Brain response to intranasal trimethylamine stimulation: A preliminary human fMRI study |
| Author(s): | Han P; Weber C; Hummel T; |
| Address: | "Interdisciplinary Center on Smell and Taste, Department of Otorhinolaryngology, TU Dresden, Dresden, Germany; Faculty of Psychology, Southwest University, Chongqing, China; The Key Laboratory of Cognition and Personality, Ministry of Education, Chongqing, China. Electronic address: p.han@foxmail.com. Interdisciplinary Center on Smell and Taste, Department of Otorhinolaryngology, TU Dresden, Dresden, Germany" |
| DOI: | 10.1016/j.neulet.2020.135166 |
| ISSN/ISBN: | 1872-7972 (Electronic) 0304-3940 (Linking) |
| Abstract: | "The trace amine-associated receptors (TAARs) are a second class of olfactory receptors in humans. They are activated by volatile amines, including pheromone-like odors. However, in humans the neural processing of TAAR-associated signals is not known. Using functional magnetic resonance imaging, the current study investigated brain activation following intra-nasal stimulation with trimethylamine (TMA), an agonist of human TAAR5, and three 'canonical' odors with varied valence (an unpleasant odor [n-butanol], a neutral to unpleasant odor [civet musk], and a pleasant odor [phenyl ethyl alcohol]) in 12 healthy young participants. Our hypothesis driven analysis showed that TMA induced a trend for stronger left amygdala activation as compared to the other odors (Family-Wise Error corrected p?ª+=?ª+0.08). Whole-brain exploratory analyses revealed superior activation of the cerebellum and caudate to TMA compared to canonical odors, and stronger activation of the anterior cingulate and somatosensory regions (postcentral gyrus and mid cingulate) in response to canonical odors compared to TMA. The current results provide initial evidence on differential central processes of a TAAR mediated stimulus compared to odors targeting canonical olfactory receptors. Future research are needed to elucidate the physiological and psychological relevance of TAARs in humans" |
| Keywords: | "Administration, Inhalation Administration, Intranasal Adult Brain/*drug effects Female Humans Magnetic Resonance Imaging Methylamines/*pharmacology Odorants Olfactory Perception/*physiology Receptors, G-Protein-Coupled/*metabolism Young Adult Left amygdal;" |
| Notes: | "MedlineHan, Pengfei Weber, Catharina Hummel, Thomas eng Ireland 2020/06/24 Neurosci Lett. 2020 Sep 14; 735:135166. doi: 10.1016/j.neulet.2020.135166. Epub 2020 Jun 20" |
