| Title: | "5alpha-cyprinol sulfate, a bile salt from fish, induces diel vertical migration in Daphnia" |
| Author(s): | Hahn MA; Effertz C; Bigler L; von Elert E; |
| Address: | "Aquatic Chemical Ecology, Department of Biology, University of Koeln, Koeln, Germany. Department of Chemistry, University of Zurich, Zurich, Switzerland" |
| ISSN/ISBN: | 2050-084X (Electronic) 2050-084X (Linking) |
| Abstract: | "Prey are under selection to minimize predation losses. In aquatic environments, many prey use chemical cues released by predators, which initiate predator avoidance. A prominent example of behavioral predator-avoidance constitutes diel vertical migration (DVM) in the freshwater microcrustacean Daphnia spp., which is induced by chemical cues (kairomones) released by planktivorous fish. In a bioassay-guided approach using liquid chromatography and mass spectrometry, we identified the kairomone from fish incubation water as 5alpha-cyprinol sulfate inducing DVM in Daphnia at picomolar concentrations. The role of 5alpha-cyprinol sulfate in lipid digestion in fish explains why from an evolutionary perspective fish has not stopped releasing 5alpha-cyprinol sulfate despite the disadvantages for the releaser. The identification of the DVM-inducing kairomone enables investigating its spatial and temporal distribution and the underlying molecular mechanism of its perception. Furthermore, it allows to test if fish-mediated inducible defenses in other aquatic invertebrates are triggered by the same compound" |
| Keywords: | "Animals Bile Acids and Salts/isolation & purification/*metabolism Biological Assay Cholestanols/isolation & purification/*metabolism Chromatography, Liquid Daphnia/*drug effects Fishes Locomotion/*drug effects Mass Spectrometry Pheromones/isolation & puri;" |
| Notes: | "MedlineHahn, Meike Anika Effertz, Christoph Bigler, Laurent von Elert, Eric eng England 2019/05/03 Elife. 2019 May 2; 8:e44791. doi: 10.7554/eLife.44791" |
