| Title: | Analyses of volatile organic compounds from human skin |
| Author(s): | Gallagher M; Wysocki CJ; Leyden JJ; Spielman AI; Sun X; Preti G; |
| Address: | "Monell Chemical Senses Center, Philadelphia, PA 19104, USA" |
| DOI: | 10.1111/j.1365-2133.2008.08748.x |
| ISSN/ISBN: | 1365-2133 (Electronic) 0007-0963 (Print) 0007-0963 (Linking) |
| Abstract: | "BACKGROUND: Human skin emits a variety of volatile metabolites, many of them odorous. Much previous work has focused upon chemical structure and biogenesis of metabolites produced in the axillae (underarms), which are a primary source of human body odour. Nonaxillary skin also harbours volatile metabolites, possibly with different biological origins than axillary odorants. OBJECTIVES: To take inventory of the volatile organic compounds (VOCs) from the upper back and forearm skin, and assess their relative quantitative variation across 25 healthy subjects. METHODS: Two complementary sampling techniques were used to obtain comprehensive VOC profiles, viz., solid-phase microextraction and solvent extraction. Analyses were performed using both gas chromatography/mass spectrometry and gas chromatography with flame photometric detection. RESULTS: Nearly 100 compounds were identified, some of which varied with age. The VOC profiles of the upper back and forearm within a subject were, for the most part, similar, although there were notable differences. CONCLUSIONS: The natural variation in nonaxillary skin odorants described in this study provides a baseline of compounds we have identified from both endogenous and exogenous sources. Although complex, the profiles of volatile constituents suggest that the two body locations share a considerable number of compounds, but both quantitative and qualitative differences are present. In addition, quantitative changes due to ageing are also present. These data may provide future investigators of skin VOCs with a baseline against which any abnormalities can be viewed in searching for biomarkers of skin diseases" |
| Keywords: | Adult Aged Biomarkers/analysis/chemistry Epidemiologic Methods Female Gas Chromatography-Mass Spectrometry/methods Humans Male Middle Aged Odorants/*analysis Organic Chemicals/*analysis/chemistry Skin/*chemistry Solid Phase Microextraction/methods Volatil; |
| Notes: | "MedlineGallagher, M Wysocki, C J Leyden, J J Spielman, A I Sun, X Preti, G eng T32 DC000014-26/DC/NIDCD NIH HHS/ T 32 DC00014-26/DC/NIDCD NIH HHS/ Research Support, N.I.H., Extramural England 2008/07/22 Br J Dermatol. 2008 Sep; 159(4):780-91. doi: 10.1111/j.1365-2133.2008.08748.x. Epub 2008 Jul 14" |
