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Microorganisms

Title:		Fecal Volatile Metabolomics Predict Gram-Negative Late-Onset Sepsis in Preterm Infants: A Nationwide Case-Control Study
Author(s):		Frerichs NM; El Manouni El Hassani S; Deianova N; van Weissenbruch MM; van Kaam AH; Vijlbrief DC; van Goudoever JB; Hulzebos CV; Kramer BW; d'Haens EJ; Cossey V; de Boode WP; de Jonge WJ; Wicaksono AN; Covington JA; Benninga MA; de Boer NKH; Niemarkt HJ; de Meij TGJ;
Address:		"Department of Pediatric Gastroenterology, Emma Children's Hospital, Amsterdam Gastroenterology Endocrinology Metabolism Research Institute, Amsterdam UMC, 1105 AZ Amsterdam, The Netherlands. Department of Neonatology, Amsterdam Reproduction and Development Research Institute, Emma Children's Hospital, 1105 AZ Amsterdam, The Netherlands. Department of Neonatology, University Medical Center Utrecht, Wilhelmina Children's Hospital, 3584 CX Utrecht, The Netherlands. Department of Neonatology, Beatrix Children's Hospital, University Medical Center Groningen, 9713 GZ Groningen, The Netherlands. Department of Pediatrics, Maastricht University Medical Centre, 6229 ER Maastricht, The Netherlands. Department of Neonatology, Isala Hospital, 8025 AB Zwolle, The Netherlands. Department of Neonatology, University Hospitals Leuven, 3000 Leuven, Belgium. Department of Neonatology, Radboud UMC, Amalia Children's Hospital, 6525 XZ Nijmegen, The Netherlands. Tytgat Institute for Liver and Intestinal Research, Amsterdam Gastroenterology Endocrinology Metabolism Research Institute, Amsterdam UMC, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands. School of Engineering, University of Warwick, Coventry CV4 7AL, UK. Department of Gastroenterology and Hepatology, Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam University Medical Centre, Vrije Universiteit Amsterdam, 1081 HZ Amsterdam, The Netherlands. Department of Neonatology, Maxima Medical Center, 5504 DB Veldhoven, The Netherlands"
Journal Title:		Microorganisms
Year:		2023
Volume:		20230224
Issue:		3
Page Number:		-
DOI:		10.3390/microorganisms11030572
ISSN/ISBN:		2076-2607 (Print) 2076-2607 (Electronic) 2076-2607 (Linking)
Abstract:		"Early detection of late-onset sepsis (LOS) in preterm infants is crucial since timely treatment initiation is a key prognostic factor. We hypothesized that fecal volatile organic compounds (VOCs), reflecting microbiota composition and function, could serve as a non-invasive biomarker for preclinical pathogen-specific LOS detection. Fecal samples and clinical data of all preterm infants (
Keywords:		fecal biomarker gas chromatography-ion mobility spectrometry gas chromatography-time of flight-mass spectrometry microbiota neonatology volatile organic compounds;
Notes:		"PubMed-not-MEDLINEFrerichs, Nina M El Manouni El Hassani, Sofia Deianova, Nancy van Weissenbruch, Mirjam M van Kaam, Anton H Vijlbrief, Daniel C van Goudoever, Johannes B Hulzebos, Christian V Kramer, Boris W d'Haens, Esther J Cossey, Veerle de Boode, Willem P de Jonge, Wouter J Wicaksono, Alfian N Covington, James A Benninga, Marc A de Boer, Nanne K H Niemarkt, Hendrik J de Meij, Tim G J eng N/A/Landelijke Vereniging van Crematoria (Dr. C.J. Vaillant Fonds)/ N/A/Zeldzame Ziekten Fonds/ 814168/European Union's Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant/ Switzerland 2023/03/30 Microorganisms. 2023 Feb 24; 11(3):572. doi: 10.3390/microorganisms11030572"