| Title: | Remarkable diversity of vomeronasal type 2 receptor (OlfC) genes of basal ray-finned fish and its evolutionary trajectory in jawed vertebrates |
| Author(s): | Zhang Z; Sakuma A; Kuraku S; Nikaido M; |
| Address: | "School of Life Science and Technology, Tokyo Institute of Technology, Tokyo, 152-8550, Japan. Institute for the Advanced Study of Human Biology, Kyoto University, Kyoto, 606-8501, Japan. Molecular Life History Laboratory, National Institute of Genetics, Shizuoka, 411-8540, Japan. Laboratory for Phyloinformatics, RIKEN Center for Biosystems Dynamics Research (BDR), Kobe, 650-0047, Japan. Department of Genetics, Graduate University for Advanced Studies, Sokendai, Shizuoka, 411-8540, Japan. School of Life Science and Technology, Tokyo Institute of Technology, Tokyo, 152-8550, Japan. mnikaido@bio.titech.ac.jp" |
| DOI: | 10.1038/s41598-022-10428-0 |
| ISSN/ISBN: | 2045-2322 (Electronic) 2045-2322 (Linking) |
| Abstract: | "The vomeronasal type 2 receptor (V2R, also called OlfC) multigene family is found in a broad range of jawed vertebrates from cartilaginous fish to tetrapods. V2Rs encode receptors for food-related amino acids in teleost fish, whereas for peptide pheromones in mammals. In addition, V2Rs of teleost fish are phylogenetically distinct from those of tetrapods, implying a drastic change in the V2R repertoire during terrestrial adaptation. To understand the process of diversification of V2Rs in vertebrates from 'fish-type' to 'tetrapod-type', we conducted an exhaustive search for V2Rs in cartilaginous fish (chimeras, sharks, and skates) and basal ray-finned fish (reedfish, sterlet, and spotted gar), and compared them with those of teleost, coelacanth, and tetrapods. Phylogenetic and synteny analyses on 1897 V2Rs revealed that basal ray-finned fish possess unexpectedly higher number of V2Rs compared with cartilaginous fish, implying that V2R gene repertoires expanded in the common ancestor of Osteichthyes. Furthermore, reedfish and sterlet possessed various V2Rs that belonged to both 'fish-type' and 'tetrapod-type', suggesting that the common ancestor of Osteichthyes possess 'tetrapod-type' V2Rs although they inhabited underwater environments. Thus, the unexpected diversity of V2Rs in basal ray-finned fish may provide insight into how the olfaction of osteichthyan ancestors adapt from water to land" |
| Keywords: | "Animals *Evolution, Molecular Fishes/genetics Mammals/genetics Multigene Family Phylogeny *Vertebrates/genetics;" |
| Notes: | "MedlineZhang, Zicong Sakuma, Atsuhiro Kuraku, Shigehiro Nikaido, Masato eng Research Support, Non-U.S. Gov't England 2022/04/21 Sci Rep. 2022 Apr 19; 12(1):6455. doi: 10.1038/s41598-022-10428-0" |
