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Insect Sci

Title:		Protease inhibitors: recent advancement in its usage as a potential biocontrol agent for insect pest management
Author(s):		Singh S; Singh A; Kumar S; Mittal P; Singh IK;
Address:		"Molecular Biology Research Laboratory, Department of Zoology, Deshbandhu College, University of Delhi, Kalkaji, New Delhi, India. Department of Botany, Hans Raj College, University of Delhi, Delhi, India"
Journal Title:		Insect Sci
Year:		2020
Volume:		20181014
Issue:		2
Page Number:		186 - 201
DOI:		10.1111/1744-7917.12641
ISSN/ISBN:		1744-7917 (Electronic) 1672-9609 (Linking)
Abstract:		"Plant-derived protease inhibitors (PIs) are a promising defensin for crop improvement and insect pest management. Although agronomist made significant efforts in utilizing PIs for managing insect pests, the potentials of PIs are still obscured. Insect ability to compensate nutrient starvation induced by dietary PI feeding using different strategies, that is, overexpression of PI-sensitive protease, expression of PI-insensitive proteases, degradation of PI, has made this innumerable collection of PIs worthless. A practical challenge for agronomist is to identify potent PI candidates, to limit insect compensatory responses and to elucidate insect compensatory and resistance mechanisms activated upon herbivory. This knowledge could be further efficiently utilized to identify potential targets for RNAi-mediated pest control. These vital genes of insects could be functionally annotated using the advanced gene-editing technique, CRISPR/Cas9. Contemporary research is exploiting different in silico and modern molecular biology techniques to utilize PIs in controlling insect pests efficiently. This review is structured to update recent advancements in this field, along with its chronological background"
Keywords:		Animals *Insect Control Phytochemicals *Protease Inhibitors PI transgenic gene stacking insect pest management protease inhibitors proteases transplastomic;
Notes:		"MedlineSingh, Sujata Singh, Archana Kumar, Sumit Mittal, Pooja Singh, Indrakant K eng SB/FT/LS-188/2012/Science and Engineering Research Board/ SB/YS/LS-59/2013/Science and Engineering Research Board/ Department of Science and Technology/ Review Australia 2018/09/20 Insect Sci. 2020 Apr; 27(2):186-201. doi: 10.1111/1744-7917.12641. Epub 2018 Oct 14"