| Title: | Sensor arrays based on nanoparticles for early detection of kidney injury by breath samples |
| Author(s): | Nakhleh MK; Amal H; Awad H; Gharra A; Abu-Saleh N; Jeries R; Haick H; Abassi Z; |
| Address: | "Department of Chemical Engineering and Russell Berrie Nanotechnology Institute, Technion-Israel Institute of Technology, Haifa, Israel. Department of Physiology and Biophysics, Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel. Department of Chemical Engineering and Russell Berrie Nanotechnology Institute, Technion-Israel Institute of Technology, Haifa, Israel. Electronic address: hhossam@technion.ac.il. Department of Physiology and Biophysics, Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel; Research Unit, Rambam Health Campus, Hiafa, Israel" |
| DOI: | 10.1016/j.nano.2014.06.007 |
| ISSN/ISBN: | 1549-9642 (Electronic) 1549-9634 (Linking) |
| Abstract: | "The outcomes of acute kidney injury (AKI) could be severe and even lethal, if not diagnosed in its early stages and treated appropriately. Blood and urine biomarkers, currently in use as indicators for kidney function, are either inaccurate in various cases or not timely. We report on dramatic changes in exhaled breath composition, associated with kidney dysfunction after ischemic insult in rat models. Gas chromatography linked mass spectrometry examination of breath samples indicated significant elevations in the concentration of three exhaled volatile organic compounds, two to six hours after AKI was surgically induced. Relying on these findings, we introduce an array of sensors, based on organic-layer capped gold nanoparticles, sensitive to odor changes. The ability of the array to detect AKI via breath testing was examined and scored a sensitivity of 96%, only one hour after disease induction. FROM THE CLINICAL EDITOR: In this study, organic-layer capped gold nanoparticle-based biosensors are used to analyse breath samples in an acute kidney injury model, capitalizing on the observation that specific volatile organic compounds are present in breath samples in that condition. The authors report excellent sensitivity in as little as one hour after acute kidney injury. This method, if commercialized, may replace the current blood and urine sample analysis-based tests with a more convenient, rapid and accurate nanotechnology-based method" |
| Keywords: | "Animals Biosensing Techniques/*methods Breath Tests/*methods Gold/*chemistry Kidney/*injuries Kidney Diseases/*diagnosis Male Metal Nanoparticles/*chemistry Rats Rats, Sprague-Dawley Volatile Organic Compounds/chemistry Acute kidney injury Breath test Det;" |
| Notes: | "MedlineNakhleh, Morad K Amal, Haitham Awad, Hoda Gharra, A'laa Abu-Saleh, Niroz Jeries, Raneen Haick, Hossam Abassi, Zaid eng Research Support, Non-U.S. Gov't 2014/06/24 Nanomedicine. 2014 Nov; 10(8):1767-76. doi: 10.1016/j.nano.2014.06.007. Epub 2014 Jun 19" |
