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Molecules

Title:		"A Study of the Chemical Composition, Acute and Subacute Toxicity of Bulgarian Tanacetum parthenium Essential Oil"
Author(s):		Lechkova B; Karcheva-Bahchevanska D; Ivanov K; Todorova V; Benbassat N; Penkova N; Atanassova P; Peychev L; Hrischev P; Peychev Z; Terziev D; Ivanova S;
Address:		"Department of Pharmacognosy and Pharmaceutical Chemistry, Faculty of Pharmacy, Medical University-Plovdiv, 4002 Plovdiv, Bulgaria. Department of Anatomy, Histology and Embryology, Faculty of Medicine, Medical University-Plovdiv, 4002 Plovdiv, Bulgaria. Department of Pharmacology, Toxicology and Pharmacotherapy, Faculty of Pharmacy, Medical University-Plovdiv, 4002 Plovdiv, Bulgaria. Department of Physiology, Faculty of Medicine, Medical University-Plovdiv, 4002 Plovdiv, Bulgaria. Department of Medical Informatics, Biostatistics and E-Learning, Faculty of Public Health, Medical University-Plovdiv, 4002 Plovdiv, Bulgaria. Second Department of Internal Diseases, Section of Gastroenterology, Faculty of Medicine, Medical University-Plovdiv, 4002 Plovdiv, Bulgaria"
Journal Title:		Molecules
Year:		2023
Volume:		20230622
Issue:		13
Page Number:		-
DOI:		10.3390/molecules28134906
ISSN/ISBN:		1420-3049 (Electronic) 1420-3049 (Linking)
Abstract:		"BACKGROUND: Tanacetum parthenium (L.) Sch.Bip. (T. parthenium) is an aromatic perennial plant belonging to the Asteraceae family, also known as feverfew. It is widely distributed in various regions of Europe and other parts of the world. The plant has a rich background in the traditional medicine of many nations and has been used as a remedy for fever, pain, inflammation, asthma, rheumatism, menstrual disorders, etc. Methods: GC-MS analysis was conducted to determine the chemical composition of the isolated essential oil (EO). Using the method proposed by Litchfield and Wilcoxon, the average lethal dose (LD(50)) of the EO on Wistar rats was determined for two routes of administration: oral (p.o.) and intraperitoneal (i.p.). The subacute toxicity of the EO was also tested by oral administration of a daily dose of 1.0 g/kg body weight (BW) for 28 days. The toxicity of the EO was evaluated by observing and evaluating changes in behavior, body weight, basic hematological and serum biochemical parameters, and histopathological changes of the internal organs. RESULTS: Thirty-seven volatile organic compounds representing 94.58% of the total oil composition were tentatively detected in the obtained T. parthenium EO. The dominant compounds were camphor (45.47%), trans-chrisantenyl acetate (21.65%), camphene (9.48%), and cis-isogeraniol (5.42%). The results showed that the EO was not toxic when administered in acute oral doses. The acute mean lethal dose for intraperitoneal administration was LD(50) i.p. = 2.13 g/kg BW. In the subacute study involving administration of an oral dose of EO for 28 days, there were a number of changes in the hematological and serum biochemical parameters of the blood compared with the control group of animals. However, no symptoms of toxicity, changes in the body weight of the rats, death, or pathological changes in the histological indicators of the examined organs-brain, heart, stomach, liver, spleen and kidney-were found. Extrapolating the results obtained from the rat experiments, we can state that the EO is safe for use in doses below 1 g/kgBW for a period not exceeding one month"
Keywords:		"Animals;Rats Animals *Oils, Volatile/toxicity/chemistry Tanacetum parthenium/chemistry Bulgaria Rats, Wistar Plant Extracts/chemistry *Asteraceae Body Weight Toxicity Tests, Acute Tanacetum parthenium acute and subacute toxicity essential oil feverfew hematologic;"
Notes:		"MedlineLechkova, Borislava Karcheva-Bahchevanska, Diana Ivanov, Kalin Todorova, Velislava Benbassat, Niko Penkova, Nadya Atanassova, Pepa Peychev, Lyudmil Hrischev, Petar Peychev, Zhivko Terziev, Dimitar Ivanova, Stanislava eng Switzerland 2023/07/14 Molecules. 2023 Jun 22; 28(13):4906. doi: 10.3390/molecules28134906"