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Int J Mol Sci

Title:		The Roles of c-Jun N-Terminal Kinase (JNK) in Infectious Diseases
Author(s):		Chen J; Ye C; Wan C; Li G; Peng L; Peng Y; Fang R;
Address:		"Joint International Research Laboratory of Animal Health and Animal Food Safety, College of Veterinary Medicine, Southwest University, Chongqing 400715, China. Immunology Research Center, Medical Research Institute, Southwest University, Chongqing 402460, China. Chongqing Key Laboratory of Herbivore Science, Chongqing 400715, China"
Journal Title:		Int J Mol Sci
Year:		2021
Volume:		20210906
Issue:		17
Page Number:		-
DOI:		10.3390/ijms22179640
ISSN/ISBN:		1422-0067 (Electronic) 1422-0067 (Linking)
Abstract:		"c-Jun N-terminal kinases (JNKs) are among the most crucial mitogen-activated protein kinases (MAPKs) and regulate various cellular processes, including cell proliferation, apoptosis, autophagy, and inflammation. Microbes heavily rely on cellular signaling pathways for their effective replication; hence, JNKs may play important roles in infectious diseases. In this review, we describe the basic signaling properties of MAPKs and JNKs in apoptosis, autophagy, and inflammasome activation. Furthermore, we discuss the roles of JNKs in various infectious diseases induced by viruses, bacteria, fungi, and parasites, as well as their potential to serve as targets for the development of therapeutic agents for infectious diseases. We expect this review to expand our understanding of the JNK signaling pathway's role in infectious diseases and provide important clues for the prevention and treatment of infectious diseases"
Keywords:		Animals Apoptosis Autophagy Communicable Diseases/*enzymology/metabolism/pathology Humans *MAP Kinase Signaling System Mitogen-Activated Protein Kinase 10/*metabolism Mitogen-Activated Protein Kinase 8/*metabolism Mitogen-Activated Protein Kinase 9/*metab;
Notes:		"MedlineChen, Jing Ye, Chao Wan, Chao Li, Gang Peng, Lianci Peng, Yuanyi Fang, Rendong eng (31902256, 32172850)/National Natural Science Foundation of China/ (CARS-37)/the China Agriculture Research System of MOF and MARA/ (20211105)/the Chongqing Pig Industry Technology System/ (CXQT20004)/the Foundation for Innovation Research Group in Chongqing Universities/ Review Switzerland 2021/09/11 Int J Mol Sci. 2021 Sep 6; 22(17):9640. doi: 10.3390/ijms22179640"