| Title: | High-Pressure Photon Ionization Source for TOFMS and Its Application for Online Breath Analysis |
| Author(s): | Wang Y; Jiang J; Hua L; Hou K; Xie Y; Chen P; Liu W; Li Q; Wang S; Li H; |
| Address: | "Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences , 457 Zhongshan Road, Dalian, Liaoning 116023, People's Republic of China. University of Chinese Academy of Sciences , 19 Yuquan Road, Beijing, 100039, People's Republic of China. Department of Instrumentation and Electrical Engineering, Jilin University , Jilin, 130021, People's Republic of China" |
| DOI: | 10.1021/acs.analchem.6b01707 |
| ISSN/ISBN: | 1520-6882 (Electronic) 0003-2700 (Linking) |
| Abstract: | "Photon ionization mass spectrometry (PI-MS) is a widely used technique for the online detection of trace substances in complex matrices. In this work, a new high-pressure photon ionization (HPPI) ion source based on a vacuum ultraviolet (VUV) Kr lamp was developed for time-of-flight mass spectrometry (TOFMS). The detection sensitivity was improved by elevating the ion source pressure to about 700 Pa. A radio frequency (RF)-only quadrupole was employed as the ion guide system following the HPPI source to achieve high ion transmission efficiency. In-source collision induced dissociation (CID) was conducted for accurate chemical identification by varying the voltage between the ion source and the ion guide. The high humidity of the breath air can promote the detection of some compounds with higher ionization potentials (IPs) that could not be well detected by single photon ionization (SPI) at low pressure. Under 100% relative humidity (37 degrees C), the limits of detection down to 0.015 ppbv (parts per billion by volume) for aliphatic and aromatic hydrocarbons were obtained. This HPPI-TOFMS system was preliminarily applied for online investigations of the exhaled breath from both healthy nonsmoker and smoker subjects, demonstrating its analytical capacity for complicated gases analysis. Subsequently, several frequently reported VOCs in the breath of healthy volunteers, i.e., acetone, isoprene, 2-butanone, ethanol, acetic acid, and isopropanol, were successfully identified and quantified" |
| Keywords: | Breath Tests/*instrumentation/methods Equipment Design Exhalation Humans Ions/chemistry Mass Spectrometry/*instrumentation/methods Photons Pressure Ultraviolet Rays Vacuum Volatile Organic Compounds/*analysis; |
| Notes: | "MedlineWang, Yan Jiang, Jichun Hua, Lei Hou, Keyong Xie, Yuanyuan Chen, Ping Liu, Wei Li, Qingyun Wang, Shuang Li, Haiyang eng Research Support, Non-U.S. Gov't 2016/08/31 Anal Chem. 2016 Sep 20; 88(18):9047-55. doi: 10.1021/acs.analchem.6b01707. Epub 2016 Sep 9" |
