« Previous AbstractInfluence of microwave frequency electromagnetic radiation on terpene emission and content in aromatic plants    Next AbstractMeasuring the efficacy of insecticide treated bednets: the use of DNA fingerprinting to increase the accuracy of personal protection estimates in Tanzania »

Vet Rec

Title:		Cognitive Dysfunction in Cats: Update on Neuropathological and Behavioural Changes Plus Clinical Management
Author(s):		Sordo L; Gunn-Moore DA;
Address:		"The Royal (Dick) School of Veterinary Studies and The Roslin Institute, The University of Edinburgh, Easter Bush Campus, Roslin, UK"
Journal Title:		Vet Rec
Year:		2021
Volume:		20210112
Issue:		1
Page Number:		e3 -
DOI:		10.1002/vetr.3
ISSN/ISBN:		2042-7670 (Electronic) 0042-4900 (Linking)
Abstract:		"Cognitive dysfunction syndrome (CDS) is an established condition in cats that shares many similarities with human Alzheimer's disease (AD), where cognitive decline ultimately results in dementia. Cats with CDS display behavioural abnormalities, including excessive Vocalisation, altered Interaction with owners (increased affection/attention), altered Sleep-wake cycles, House-soiling, Disorientation (spatial and/or temporal), alterations in Activity, Anxiety, and/or Learning/memory deficits (i.e., VISHDAAL). These cats develop neuropathologies, such as accumulation of beta-amyloid and hyperphosphorylated tau deposits. Because of its similarities to those in the brains of people with cognitive impairment and AD, the domestic cat could be a natural model for human dementia studies. It is important to diagnose CDS promptly in cats, ruling out other causes for these behavioural changes, to provide effective management. Interventions include environmental enrichment (e.g., easy access to key resources, calming pheromones), dietary supplementations (e.g., Senilife, Aktivait for cats, SAMe), specific diets (e.g., containing antioxidants, medium-chain triglycerides) and, potentially, medication (e.g., selegiline or propentofylline). This article reviews the literature about CDS in cats, its causes, neuropathology, clinical signs, diagnosis and potential management options. By doing so, it furthers our understanding of this condition and allows improved health, welfare and quality of life of affected cats"
Keywords:		*Alzheimer Disease/diagnosis/therapy/veterinary Amyloid beta-Peptides/metabolism Animals Brain *Cat Diseases/diagnosis/therapy Cats *Cognitive Dysfunction/diagnosis/therapy Quality of Life amyloid-beta behaviour cognitive dysfunction syndrome diagnosis ma;
Notes:		"MedlineSordo, Lorena Gunn-Moore, Danielle A eng Review England 2021/10/16 Vet Rec. 2021 Jan; 188(1):e3. doi: 10.1002/vetr.3. Epub 2021 Jan 12"