| Title: | "Chemical composition, in vitro antitumor and pro-oxidant activities of Glandora rosmarinifolia (Boraginaceae) essential oil" |
| Author(s): | Poma P; Labbozzetta M; Notarbartolo M; Bruno M; Maggio A; Rosselli S; Sajeva M; Zito P; |
| Address: | "Department of Health Sciences and Mother and Child Care 'G. D'Alessandro'(PROSAMI), Pharmacology Unit, University of Palermo, Palermo, Italy. Department of Biological, Chemical and Pharmaceutical Science and Technology (STEBICEF), University of Palermo, Palermo, Italy" |
| DOI: | 10.1371/journal.pone.0196947 |
| ISSN/ISBN: | 1932-6203 (Electronic) 1932-6203 (Linking) |
| Abstract: | "The biological properties of essential oils have been demonstrated in the treatment of several diseases and to enhance the bioavailability of other drugs. In natural habitats the essential oils compounds may play important roles in the protection of the plants as antibacterials, antivirals, antifungals, insecticides and also against herbivores by reducing their appetite for such plants or by repelling undesirable others. We analyzed by gas-chromatography mass spectrometry the chemical composition of the essential oil of aerial parts of Glandora rosmarinifolia (Ten.) D.C. Thomas obtained by hydrodistillation and verified some biological activities on a panel of hepatocellular carcinoma cell lines (HA22T/VGH, HepG2, Hep3B) and triple negative breast cancer cell lines (SUM 149, MDA-MB-231). In the essential oil we detected 35 compounds. The results of the biological assays indicate that essential oil of G. rosmarinifolia induces cell growth inhibition at concentration-dependent way in all cell line models. This oil does not seem to possess antioxidant activity, while the cytotoxicity of G. rosmarinifolia essential oil appeared to involve, at least in part, a pro-oxidant mechanism. Our results show for the first time the antitumoral and pro-oxidant activities of G. rosmarinifolia essential oil and suggest that it may represent a resource of pharmacologically active compounds" |
| Keywords: | "Antineoplastic Agents, Phytogenic/chemistry/isolation & purification/*pharmacology Boraginaceae/*chemistry Cell Line, Tumor Cell Survival/drug effects Dose-Response Relationship, Drug Epithelial Cells/drug effects/pathology Hepatocytes/drug effects/pathol;" |
| Notes: | "MedlinePoma, Paola Labbozzetta, Manuela Notarbartolo, Monica Bruno, Maurizio Maggio, Antonella Rosselli, Sergio Sajeva, Maurizio Zito, Pietro eng Research Support, Non-U.S. Gov't 2018/05/04 PLoS One. 2018 May 3; 13(5):e0196947. doi: 10.1371/journal.pone.0196947. eCollection 2018" |
