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Molecules

Title:		Breath Biomarkers in Diagnostic Applications
Author(s):		Pham YL; Beauchamp J;
Address:		"Department of Sensory Analytics and Technologies, Fraunhofer Institute for Process Engineering and Packaging IVV, Giggenhauser Strasse 35, 85354 Freising, Germany. Department of Chemistry and Pharmacy, Chair of Aroma and Smell Research, Friedrich-Alexander-Universitat Erlangen-Nurnberg, Henkestrasse 9, 91054 Erlangen, Germany"
Journal Title:		Molecules
Year:		2021
Volume:		20210911
Issue:		18
Page Number:		-
DOI:		10.3390/molecules26185514
ISSN/ISBN:		1420-3049 (Electronic) 1420-3049 (Linking)
Abstract:		"The detection of chemical compounds in exhaled human breath presents an opportunity to determine physiological state, diagnose disease or assess environmental exposure. Recent advancements in metabolomics research have led to improved capabilities to explore human metabolic profiles in breath. Despite some notable challenges in sampling and analysis, exhaled breath represents a desirable medium for metabolomics applications, foremost due to its non-invasive, convenient and practically limitless availability. Several breath-based tests that target either endogenous or exogenous gas-phase compounds are currently established and are in practical and/or clinical use. This review outlines the concept of breath analysis in the context of these unique tests and their applications. The respective breath biomarkers targeted in each test are discussed in relation to their physiological production in the human body and the development and implementation of the associated tests. The paper concludes with a brief insight into prospective tests and an outlook of the future direction of breath research"
Keywords:		"Biomarkers/*analysis Breath Tests Chemistry Techniques, Analytical Exhalation Humans Metabolomics Volatile Organic Compounds/analysis clinical practice exhaled biomarkers exhaled breath volatile organic compounds;"
Notes:		"MedlinePham, Y Lan Beauchamp, Jonathan eng 01KT1803A/Bundesministerium fur Bildung und Forschung/ Review Switzerland 2021/09/29 Molecules. 2021 Sep 11; 26(18):5514. doi: 10.3390/molecules26185514"