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Molecules

Title:		GC-MS/MS Method for Determination of Polycyclic Aromatic Hydrocarbons in Herbal Medicines
Author(s):		Park J; Kim K; Ryu D; Whang JH; Mah JH;
Address:		"Herbal Medicine Research Division, Ministry of Food and Drug Safety, Cheongju 28159, Republic of Korea. Department of Biotechnology, Korea University, Seoul 02841, Republic of Korea. Department of Food and Biotechnology, Korea University, Sejong 30019, Republic of Korea"
Journal Title:		Molecules
Year:		2023
Volume:		20230502
Issue:		9
Page Number:		-
DOI:		10.3390/molecules28093853
ISSN/ISBN:		1420-3049 (Electronic) 1420-3049 (Linking)
Abstract:		"Polycyclic aromatic hydrocarbons (PAHs) are hydrophobic organic contaminants that have a highly carcinogenic and mutagenic nature. This study aimed to develop and validate a sensitive analytical method to determine 8 PAHs in 51 herbal medicines (HMs) using gas chromatography (GC)-tandem mass spectrometry (MS/MS). Liquid--liquid extraction and florisil SPE cartridge purification were basically adopted for pretreatment. For the samples containing essential oil, starch grain, etc., N,N-dimethyl formamide/water mixture (9:1, v/v) was added in the extraction step. The multiple reaction monitoring (MRM) conditions were newly obtained by the infusion of reference solutions of the targeted compounds at a concentration of 100 ng/mL into the GC-MS/MS system used in this study. The 51 items were classified according to whether or not they contained essential oil. Eight PAHs were not detected in 39 (8.3%) of the 459 samples monitored. The total content of 8 PAHs ranged from 0.45 mug/kg in Anemarrhenae Rhizoma to 270.94 mug/kg in Zingiberis Rhizoma. The average content of those ranged from 0.9 mug/kg in Araliae Continentalis Radix to 110.8 mug/kg in Coptidis Rhizoma Preparata cum Vinum. The results of this study prove that the proposed method is useful for determining 8 PAHs in HMs"
Keywords:		"Gas Chromatography-Mass Spectrometry/methods *Polycyclic Aromatic Hydrocarbons/chemistry Tandem Mass Spectrometry/methods *Oils, Volatile Gc-ms/ms herbal medicine monitoring polycyclic aromatic hydrocarbon validation;"
Notes:		"MedlinePark, Jwahaeng Kim, Kyuyeob Ryu, Dayoun Whang, Jin-Hee Mah, Jae-Hyung eng 19171MFDS193/Ministry of Food and Drug Safety/ Switzerland 2023/05/13 Molecules. 2023 May 2; 28(9):3853. doi: 10.3390/molecules28093853"