| Title: | Epigenetic control and the circadian clock: linking metabolism to neuronal responses |
| Author(s): | Orozco-Solis R; Sassone-Corsi P; |
| Address: | "Center for Epigenetics and Metabolism, Unite 904 INSERM, Department of Biological Chemistry, University of California, Irvine, CA 92697, United States. Center for Epigenetics and Metabolism, Unite 904 INSERM, Department of Biological Chemistry, University of California, Irvine, CA 92697, United States. Electronic address: psc@uci.edu" |
| DOI: | 10.1016/j.neuroscience.2014.01.043 |
| ISSN/ISBN: | 1873-7544 (Electronic) 0306-4522 (Print) 0306-4522 (Linking) |
| Abstract: | "Experimental and epidemiological evidence reveal the profound influence that industrialized modern society has imposed on human social habits and physiology during the past 50 years. This drastic change in life-style is thought to be one of the main causes of modern diseases including obesity, type 2 diabetes, mental illness such as depression, sleep disorders, and certain types of cancer. These disorders have been associated to disruption of the circadian clock, an intrinsic time-keeper molecular system present in virtually all cells and tissues. The circadian clock is a key element in homeostatic regulation by controlling a large array of genes implicated in cellular metabolism. Importantly, intimate links between epigenetic regulation and the circadian clock exist and are likely to prominently contribute to the plasticity of the response to the environment. In this review, we summarize some experimental and epidemiological evidence showing how environmental factors such as stress, drugs of abuse and changes in circadian habits, interact through different brain areas to modulate the endogenous clock. Furthermore we point out the pivotal role of the deacetylase silent mating-type information regulation 2 homolog 1 (SIRT1) as a molecular effector of the environment in shaping the circadian epigenetic landscape" |
| Keywords: | "Animals Brain/*metabolism/physiology/physiopathology Circadian Clocks/*genetics/physiology *Epigenesis, Genetic Humans Male Sirtuin 1/physiology Stress, Psychological/genetics/physiopathology Sirt1 clock epigenetic mechanism metabolism nutrients social ze;neuroscience;" |
| Notes: | "MedlineOrozco-Solis, R Sassone-Corsi, P eng R21 DA035600/DA/NIDA NIH HHS/ Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review 2014/02/04 Neuroscience. 2014 Apr 4; 264:76-87. doi: 10.1016/j.neuroscience.2014.01.043. Epub 2014 Jan 31" |
