| Title: | Herbicide and Cytogenotoxic Activity of Inclusion Complexes of Psidium gaudichaudianum Leaf Essential Oil and beta-Caryophyllene on 2-Hydroxypropyl-beta-cyclodextrin |
| Author(s): | Mendes LA; Vasconcelos LC; Fontes MMP; Martins GS; Bergamin ADS; Silva MA; Silva RRA; Oliveira TV; Souza VGL; Ferreira M; Teixeira RR; Lopes RP; |
| Address: | "Departament of Chemistry, Federal University of Vicosa (UFV), Av. Peter Henry Rolfs, s/n, Campus Universitario, Vicosa 36570-000, MG, Brazil. Department of Biology, Federal University of Espirito Santo (UFES), Alto Universitario, s/n, Guararema, Alegre 29500-000, ES, Brazil. Department of Agronomy, Federal University of Espirito Santo (UFES), Alto Universitario, s/n, Guararema, Alegre 29500-000, ES, Brazil. Departament of Food Materials Science and Engineering, Federal University of Sao Carlos (UFSCar), Rod. Washington Luiz, s/n, Sao Carlos 13565-905, SP, Brazil. Department of Food Technology, Federal University of Vicosa, Vicosa 36570-900, MG, Brazil. International Iberian Nanotechnology Laboratory (INL), Av. Mestre Jose Veiga s/n, 4715-330 Braga, Portugal. MEtRICs, CubicB, Departament of Chemistry, NOVA School of Science and Technology (FCT NOVA), University Nova de Lisboa, Campus de Caparica, 2829-516 Caparica, Portugal" |
| DOI: | 10.3390/molecules28155909 |
| ISSN/ISBN: | 1420-3049 (Electronic) 1420-3049 (Linking) |
| Abstract: | "The present investigation aimed to develop inclusion complexes (ICs) from Psidium gaudichaudianum (GAU) essential oil (EO) and its major compound beta-caryophyllene (beta-CAR), and to evaluate their herbicidal (against Lolium multiflorum and Bidens pilosa) and cytogenotoxic (on Lactuca sativa) activities. The ICs were obtained using 2-hydroxypropyl-beta-cyclodextrin (HPbetaCD) and they were prepared to avoid or reduce the volatility and degradation of GAU EO and beta-CAR. The ICs obtained showed a complexation efficiency of 91.5 and 83.9% for GAU EO and beta-CAR, respectively. The IC of GAU EO at a concentration of 3000 microg mL(-1) displayed a significant effect against weed species B. pilosa and L. multiflorum. However, the beta-CAR IC at a concentration of 3000 microg mL(-1) was effective only on L. multiflorum. In addition, the cytogenotoxic activity evaluation revealed that there was a reduction in the mitotic index and an increase in chromosomal abnormalities. The produced ICs were able to protect the EO and beta-CAR from volatility and degradation, with a high thermal stability, and they also enabled the solubilization of the EO and beta-CAR in water without the addition of an organic solvent. Therefore, it is possible to indicate the obtained products as potential candidates for commercial exploration since the ICs allow the complexed EO to exhibit a more stable chemical constitution than pure EO under storage conditions" |
| Keywords: | "2-Hydroxypropyl-beta-cyclodextrin/chemistry *Herbicides/pharmacology/analysis *Oils, Volatile/chemistry Plant Leaves/chemistry *Psidium/chemistry Solubility araca bioherbicide biological activity inclusion complex natural product;" |
| Notes: | "MedlineMendes, Luiza Alves Vasconcelos, Loren Cristina Fontes, Milene Miranda Praca Martins, Geisiele Silva Bergamin, Aline Dos Santos Silva, Matheus Alves Silva, Rafael Resende Assis Oliveira, Taila Veloso de Souza, Victor Gomes Lauriano Ferreira, Marcia Flores da Silva Teixeira, Robson Ricardo Lopes, Renata Pereira eng CAPES/Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior/ CNPq/National Council for Scientific and Technological Development/ FAPEMIG/Fundacao de Amparo a Pesquisa do Estado de Minas Gerais/ FAPES/Fundacao de Amparo a Pesquisa do Espirito Santo/ Switzerland 2023/08/12 Molecules. 2023 Aug 6; 28(15):5909. doi: 10.3390/molecules28155909" |
