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Horm Behav

Title:		Mistimed restricted feeding disrupts circadian rhythms of male mating behavior and female preovulatory LH surges in mice
Author(s):		Kukino A; Walbeek TJ; Sun LJ; Watt AT; Park JH; Kauffman AS; Butler MP;
Address:		"Oregon Institute of Occupational Health Sciences, Oregon Health & Science University, Portland, OR, United States of America. Department of Psychology, University of Massachusetts, Boston, MA, United States of America. Department of OBGYN and Reproductive Sciences, University of California, San Diego, La Jolla, CA, United States of America. Oregon Institute of Occupational Health Sciences, Oregon Health & Science University, Portland, OR, United States of America; Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, OR, United States of America. Electronic address: butlema@ohsu.edu"
Journal Title:		Horm Behav
Year:		2022
Volume:		20220831
Issue:
Page Number:		105242 -
DOI:		10.1016/j.yhbeh.2022.105242
ISSN/ISBN:		1095-6867 (Electronic) 0018-506X (Print) 0018-506X (Linking)
Abstract:		"In rodents, eating at atypical circadian times, such as during the biological rest phase when feeding is normally minimal, reduces fertility. Prior findings suggest this fertility impairment is due, at least in part, to reduced mating success. However, the physiological and behavioral mechanisms underlying this reproductive suppression are not known. In the present study, we tested the hypothesis that mistimed feeding-induced infertility is due to a disruption in the normal circadian timing of mating behavior and/or the generation of pre-ovulatory luteinizing hormone (LH) surges (estrogen positive feedback). In the first experiment, male+female mouse pairs, acclimated to be food restricted to either the light (mistimed feeding) or dark (control feeding) phase, were scored for mounting frequency and ejaculations over 96 h. Male mounting behavior and ejaculations were distributed much more widely across the day in light-fed mice than in dark-fed controls and fewer light-fed males ejaculated. In the second experiment, the timing of the LH surge, a well characterized circadian event driven by estradiol (E2) and the SCN, was analyzed from serial blood samples taken from ovariectomized and E2-primed female mice that were light-, dark-, or ad-lib-fed. LH concentrations peaked 2 h after lights-off in both dark-fed and ad-lib control females, as expected, but not in light-fed females. Instead, the normally clustered LH surges were distributed widely with high inter-mouse variability in the light-fed group. These data indicate that mistimed feeding disrupts the temporal control of the neural processes underlying both ovulation and mating behavior, contributing to infertility"
Keywords:		Animals *Circadian Rhythm *Eating Estradiol/pharmacology Estrogens Female *Infertility Luteinizing Hormone Male Mice Circadian GnRH LH surge Positive feedback Reproduction Reproductive behavior Sex behavior Trf;neuroscience;
Notes:		"MedlineKukino, Ayaka Walbeek, Thijs J Sun, Lori J Watt, Alexander T Park, Jin Ho Kauffman, Alexander S Butler, Matthew P eng R01 HD090161/HD/NICHD NIH HHS/ R01 NS102962/NS/NINDS NIH HHS/ Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't 2022/09/03 Horm Behav. 2022 Sep; 145:105242. doi: 10.1016/j.yhbeh.2022.105242. Epub 2022 Aug 31"