| Title: | Methyl jasmonate induces apoptosis through induction of Bax/Bcl-XS and activation of caspase-3 via ROS production in A549 cells |
| Author(s): | Kim JH; Lee SY; Oh SY; Han SI; Park HG; Yoo MA; Kang HS; |
| Address: | "Department of Molecular Biology, College of Natural Sciences, Pusan National University, Pusan 609-735, Korea" |
| ISSN/ISBN: | 1021-335X (Print) 1021-335X (Linking) |
| Abstract: | "Jasmonates are plant lipid derivatives, similar to mammalian eicosanoid, that play a critical role(s) in plant defenses against herbivores and pathogens through up-regulating the expression of defense-related genes. Recently, jasmonates were shown to induce cell cycle arrest or apoptosis in human leukemia, prostate and breast cancer cells, but not in normal lymphocytes, suggesting that the chemicals can be used as a novel class of anti-cancer drugs. In the present study, we examined the molecular mechanism that contributes to methyl jasmonate-induced apoptosis. Herein we show that methyl jasmonate induces apoptosis through induction of Bax/Bcl-XS and activation of caspase-3 via reactive oxygen species production in A549 human lung adenocarcinoma cells" |
| Keywords: | "Acetates/*pharmacology Adenocarcinoma/metabolism Apoptosis/*physiology Blotting, Western Caspase 3 Caspases/drug effects/metabolism Cell Line, Tumor Cyclopentanes/*pharmacology Electrophoresis, Polyacrylamide Gel Enzyme Activation/drug effects/physiology;" |
| Notes: | "MedlineKim, Ji Hye Lee, Su Yeon Oh, Su Young Han, Song Iy Park, Hye Gyeong Yoo, Mi-Ae Kang, Ho Sung eng Research Support, Non-U.S. Gov't Greece 2004/11/18 Oncol Rep. 2004 Dec; 12(6):1233-8" |
