| Title: | The effects of two stressors on working memory and cognitive flexibility in zebrafish (Danio rerio): The protective role of D1/D5 agonist on stress responses |
| Author(s): | Fontana BD; Cleal M; Gibbon AJ; McBride SD; Parker MO; |
| Address: | "Brain and Behaviour Laboratory, School of Pharmacy and Biomedical Sciences, University of Portsmouth, UK. Electronic address: barbara.fontana@port.ac.uk. Brain and Behaviour Laboratory, School of Pharmacy and Biomedical Sciences, University of Portsmouth, UK. Aberystwyth University, Penglais, Aberystwyth, Ceredigion, UK. Brain and Behaviour Laboratory, School of Pharmacy and Biomedical Sciences, University of Portsmouth, UK. Electronic address: matthew.parker@port.ac.uk" |
| DOI: | 10.1016/j.neuropharm.2021.108681 |
| ISSN/ISBN: | 1873-7064 (Electronic) 0028-3908 (Linking) |
| Abstract: | "Acute stressors are recurrent in multiple species' lives and can facilitate or impair cognition. The use of zebrafish (Danio rerio) as a translational species to understand the mechanisms by which stress induces different behavioral phenotypes has been widely studied. Two acute stressors are recognized when using this species: (1) conspecific alarm substance (CAS); and (2) net chasing. Here, we tested if CAS or net chasing would affect working memory and cognitive flexibility by testing performance in the FMP Y-maze after exposure to stress. We observed that CAS altered zebrafish behavioral phenotypes by increasing repetitive behavior; meanwhile, animals showed different patterns of repetitive behavior when exposed to net chasing, depending on the chasing direction. Because D1 receptors were previously studied as a potential mechanism underlying stress responses in different species, here, we pretreated fish with a D1/D5 agonist (SKF-38393) to assess whether this system plays a role in repetitive behavior in the FMP Y-maze. The pretreatment with D1/D5 agonist significantly decreased repetitive behavior in CAS exposed animals, and cortisol levels for both stressed groups, suggesting that the dopaminergic system plays an important role in zebrafish stress-related responses" |
| Keywords: | "2, 3, 4, 5-Tetrahydro-7, 8-dihydroxy-1-phenyl-1H-3-benzazepine/pharmacology Animals Behavior, Animal/drug effects/*physiology Cognition/drug effects/*physiology Dopamine Agonists/pharmacology Hydrocortisone/*metabolism Maze Learning/drug effects/physiology Me;" |
| Notes: | "MedlineFontana, Barbara D Cleal, Madeleine Gibbon, Alistair J McBride, Sebastian D Parker, Matthew O eng Research Support, Non-U.S. Gov't England 2021/06/28 Neuropharmacology. 2021 Sep 15; 196:108681. doi: 10.1016/j.neuropharm.2021.108681. Epub 2021 Jun 24" |
