| Title: | Analysis of volatile organic compounds: an innovative approach to heart failure characterization in older patients |
| Author(s): | Finamore P; Pedone C; Lelli D; Costanzo L; Bartoli IR; De Vincentis A; Grasso S; Parente FR; Pennazza G; Santonico M; Incalzi RA; |
| Address: | "Unit of Geriatrics, Campus Bio-Medico University, via Alvaro del Portillo 200, I-00128 Rome, Italy" |
| ISSN/ISBN: | 1752-7163 (Electronic) 1752-7155 (Linking) |
| Abstract: | "BACKGROUND: Analysis of exhaled volatile organic compounds (VOCs) may be applied for diagnostic purposes in some chronic diseases, but there are no data on their role for discriminating people with congestive heart failure (CHF), particularly in older patients where natriuretic peptides have lower accuracy. We evaluated whether VOCs analysis can discriminate patients with or without CHF, stratify CHF severity and predict the response to therapy of decompensated CHF. METHODS AND RESULTS: We recruited 89 subjects admitted to an acute care ward with acutely decompensated CHF, 117 healthy controls and 103 chronic obstructive pulmonary disease (COPD) controls. CHF patients performed echocardiography. VOCs were collected using the Pneumopipe((R)) and analyzed with the BIONOTE electronic nose. Partial least square analysis was used to evaluate the discriminative capacity of VOCs. Accuracy in discrimination of CHF versus healthy and COPD controls was 81% and 69%, respectively; accuracy did not decrease in a sensitivity analysis excluding subjects younger than 65 and older than 80 years. In CHF patients VOCs pattern could predict with fair precision ejection fraction and systolic pulmonary arterial pressure, but not changes in weight due to therapy. CONCLUSIONS: VOCs pattern is able to discriminate older CHF patients from healthy people and COPD patients and correlates with cardiac function markers" |
| Keywords: | "Aged Aged, 80 and over Blood Pressure Breath Tests Case-Control Studies Discriminant Analysis Exhalation Female Heart Failure/*diagnosis Humans Least-Squares Analysis Male Middle Aged Pulmonary Disease, Chronic Obstructive/diagnosis/physiopathology Respir;" |
| Notes: | "MedlineFinamore, P Pedone, C Lelli, D Costanzo, L Bartoli, I Rossi De Vincentis, A Grasso, S Parente, F Romana Pennazza, G Santonico, M Incalzi, R Antonelli eng England 2018/02/07 J Breath Res. 2018 Feb 6; 12(2):026007. doi: 10.1088/1752-7163/aa8cd4" |
