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J Biol Chem

Title:		Heterotrimeric G Protein-coupled Receptor Signaling in Yeast Mating Pheromone Response
Author(s):		Alvaro CG; Thorner J;
Address:		"From the Division of Biochemistry, Biophysics and Structural Biology, Department of Molecular and Cell Biology, University of California, Berkeley, California 94720-3202. From the Division of Biochemistry, Biophysics and Structural Biology, Department of Molecular and Cell Biology, University of California, Berkeley, California 94720-3202 jthorner@berkeley.edu"
Journal Title:		J Biol Chem
Year:		2016
Volume:		20160223
Issue:		15
Page Number:		7788 - 7795
DOI:		10.1074/jbc.R116.714980
ISSN/ISBN:		1083-351X (Electronic) 0021-9258 (Print) 0021-9258 (Linking)
Abstract:		"The DNAs encoding the receptors that respond to the peptide mating pheromones of the budding yeastSaccharomyces cerevisiaewere isolated in 1985, and were the very first genes for agonist-binding heterotrimeric G protein-coupled receptors (GPCRs) to be cloned in any organism. Now, over 30 years later, this yeast and its receptors continue to provide a pathfinding experimental paradigm for investigating GPCR-initiated signaling and its regulation, as described in this retrospective overview"
Keywords:		"DNA, Fungal/genetics Gene Expression Regulation, Fungal Heterotrimeric GTP-Binding Proteins/genetics/*metabolism MAP Kinase Signaling System Pheromones/genetics/*metabolism Receptors, G-Protein-Coupled/genetics/*metabolism Receptors, Pheromone/genetics/me;"
Notes:		"MedlineAlvaro, Christopher G Thorner, Jeremy eng R01 GM021841/GM/NIGMS NIH HHS/ T32 GM007232/GM/NIGMS NIH HHS/ GM07232/GM/NIGMS NIH HHS/ GM21841/GM/NIGMS NIH HHS/ Research Support, N.I.H., Extramural Review 2016/02/26 J Biol Chem. 2016 Apr 8; 291(15):7788-95. doi: 10.1074/jbc.R116.714980. Epub 2016 Feb 23"