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Neurobiol Learn Mem

Title:		"Cognitive, emotional and social phenotyping of mice in an observer-independent setting"
Author(s):		Dere E; Ronnenberg A; Tampe B; Arinrad S; Schmidt M; Zeisberg E; Ehrenreich H;
Address:		"Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Gottingen, Germany; DFG Research Center for Nanoscale Microscopy and Molecular Physiology of the Brain (CNMPB), Gottingen, Germany. Electronic address: dere@em.mpg.de. Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Gottingen, Germany. Nephrology and Rheumatology, University Medical Center, Georg-August-University, Gottingen, Germany. Emmy Noether-Group Somatosensory Signaling and Systems Biology, Max Planck Institute of Experimental Medicine, Gottingen, Germany. Department of Cardiology and Pneumology, University Medical Center of Gottingen, Georg-August University, Gottingen, Germany; German Center for Cardiovascular Research (DZHK), Gottingen, Germany. Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Gottingen, Germany; DFG Research Center for Nanoscale Microscopy and Molecular Physiology of the Brain (CNMPB), Gottingen, Germany. Electronic address: ehrenreich@em.mpg.de"
Journal Title:		Neurobiol Learn Mem
Year:		2018
Volume:		20180221
Issue:
Page Number:		136 - 150
DOI:		10.1016/j.nlm.2018.02.023
ISSN/ISBN:		1095-9564 (Electronic) 1074-7427 (Linking)
Abstract:		"Based on the intellicage paradigm, we have developed a novel cognitive, emotional and social phenotyping battery that permits comprehensive standardized behavioral characterization of mice in an experimenter-independent social setting. Evaluation of this battery in a large number of male and female C57BL/6 wildtype mice, tested in >20 independent cohorts, revealed high reproducibility of the behavioral readouts and may serve as future reference tool. We noticed robust sex-specific differences in general activity, cognitive and emotional behavior, but not regarding preference for social pheromones. Specifically, female mice revealed higher activity, decreased sucrose preference, impaired reversal and place-time-reward learning. Furthermore, female mice reacted more sensitively than males to reward-withdrawal showing a negative emotional contrast/Crespi-effect. In a series of validation experiments, we tested mice with different pathologies, including neuroligin-3 deficient mice (male Nlgn3(y/-) and female Nlgn3(+/-)) for autistic behavior, oligodendrocyte-specific erythropoietin receptor knockout (oEpoR(-/-)) mice for cognitive impairment, as well as mouse models of renal failure (unilateral ureteral obstruction and 5/6 nephrectomy) and of type 2 diabetes (ApoE(-/-)) - for delineating potentially confounding effects of motivational factors (thirst, glucose-craving) on learning and memory assessments. As prominent features, we saw in Nlgn3 mutants reduced preference for social pheromones, whereas oEpoR(-/-) mice showed learning deficits in place or reversal learning tasks. Renal failure led to increased water intake, and diabetic metabolism to enhanced glucose preference, limiting interpretation of hereon based learning and memory performance in these mice. The phenotyping battery presented here may be well-suited as high-throughput multifaceted diagnostic instrument for translational neuropsychiatry and behavioral genetics"
Keywords:		"Animals Behavior, Animal/*physiology Cognition/*physiology Emotions/*physiology Exploratory Behavior/physiology Female Learning/*physiology Male Mice Mice, Inbred C57BL Mice, Knockout *Phenotype *Social Behavior Episodic-like memory Extinction learning Mo;"
Notes:		"MedlineDere, Ekrem Ronnenberg, Anja Tampe, Bjorn Arinrad, Sahab Schmidt, Manuela Zeisberg, Elisabeth Ehrenreich, Hannelore eng Research Support, Non-U.S. Gov't 2018/02/24 Neurobiol Learn Mem. 2018 Apr; 150:136-150. doi: 10.1016/j.nlm.2018.02.023. Epub 2018 Feb 21"